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Fig. 4 | Journal of Hematology & Oncology

Fig. 4

From: A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors

Fig. 4

NLRs/inflammasome sensors may be either upstream regulators or downstream targets of nuclear receptors in human tissues (tissues: adipose, brain, eye, heart, kidney, liver, lymph node, muscle, pancreas, skin, spleen). a Correlation between inflammasome genes and highly expressed nuclear receptors. b Different correlation tiers show the level of statistically significant correlation between inflammasome genes and highly expressed nuclear receptors. Abbreviations: NOD1/2/3/4: nucleotide-binding oligomerization domain-like receptors 1/2/3/4; NALP2/3/6/9/14: NLR family pyrin domain containing 2/3/6/9/14; NAIP: NLR family apoptosis inhibitory protein; NLRC4: NLR family CARD domain containing 4; ASC: PYD and CARD domain containing; IFI16: interferon gamma-inducible protein 16; CARD8: caspase recruitment domain family member 8

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