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Table 11 Hormone ligand level changes are associated with inflammatory diseases

From: A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors

NRNC symbol Ligand(s) Inflammatory disease Ligand level change PMID
Class I—thyroid hormone receptor-like
 NR1A1 Thyroid hormone Inflammatory bowel diseases 8562993
 NR1A2
 NR1B1 Vitamin A Chronic obstructive pulmonary disease 26339144
 NR1B2
 NR1B3
 NR1C1 Fatty acids, prostaglandins Inflammatory bowel disease 27631140
 NR1C2
 NR1C3
 NR1F1 Cholesterol Atherosclerotic cardiovascular disease 21686232
 NR1F2
 NR1F3
 NR1H3 Oxysterols Inflammatory bowel diseases 24024145
 NR1H2
 NR1H4
Class II—retinoid X receptor-like
 NR2B1 Retinoids Inflammatory intestinal disease 23690441
 NR2B2
 NR2B3
Class III—estrogen receptor-like
 NR3A1 Estrogens Atherosclerosis 12816884
 NR3C1 Cortisol Obesity 12466357
 NR3C2 Aldosterone Renal fibrosis 26730742
 NR3C4 Testosterone Crohn’s disease 26020563