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Table 11 Hormone ligand level changes are associated with inflammatory diseases

From: A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors

NRNC symbol Ligand(s) Inflammatory disease Ligand level change PMID
Class I—thyroid hormone receptor-like
 NR1A1 Thyroid hormone Inflammatory bowel diseases 8562993
 NR1B1 Vitamin A Chronic obstructive pulmonary disease 26339144
 NR1C1 Fatty acids, prostaglandins Inflammatory bowel disease 27631140
 NR1F1 Cholesterol Atherosclerotic cardiovascular disease 21686232
 NR1H3 Oxysterols Inflammatory bowel diseases 24024145
Class II—retinoid X receptor-like
 NR2B1 Retinoids Inflammatory intestinal disease 23690441
Class III—estrogen receptor-like
 NR3A1 Estrogens Atherosclerosis 12816884
 NR3C1 Cortisol Obesity 12466357
 NR3C2 Aldosterone Renal fibrosis 26730742
 NR3C4 Testosterone Crohn’s disease 26020563