Table 11 Hormone ligand level changes are associated with inflammatory diseases
NRNC symbol | Ligand(s) | Inflammatory disease | Ligand level change | PMID |
|---|---|---|---|---|
Class I—thyroid hormone receptor-like | ||||
 NR1A1 | Thyroid hormone | Inflammatory bowel diseases | ↑ | 8562993 |
 NR1A2 | ||||
 NR1B1 | Vitamin A | Chronic obstructive pulmonary disease | ↓ | 26339144 |
 NR1B2 | ||||
 NR1B3 | ||||
 NR1C1 | Fatty acids, prostaglandins | Inflammatory bowel disease | ↓ | 27631140 |
 NR1C2 | ||||
 NR1C3 | ||||
 NR1F1 | Cholesterol | Atherosclerotic cardiovascular disease | ↑ | 21686232 |
 NR1F2 | ||||
 NR1F3 | ||||
 NR1H3 | Oxysterols | Inflammatory bowel diseases | ↑ | 24024145 |
 NR1H2 | ||||
 NR1H4 | ||||
Class II—retinoid X receptor-like | ||||
 NR2B1 | Retinoids | Inflammatory intestinal disease | ↓ | 23690441 |
 NR2B2 | ||||
 NR2B3 | ||||
Class III—estrogen receptor-like | ||||
 NR3A1 | Estrogens | Atherosclerosis | ↓ | 12816884 |
 NR3C1 | Cortisol | Obesity | ↑ | 12466357 |
 NR3C2 | Aldosterone | Renal fibrosis | ↑ | 26730742 |
 NR3C4 | Testosterone | Crohn’s disease | ↓ | 26020563 |