A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors

Table 16 Pro-inflammatory cytokine signaling negatively regulates the expression of nuclear receptors

Disease		Tissue/cell type	Number		Upregulated gene	Fold*	Downregulated gene	Fold*	PMID/GEO ID
Disease		Tissue/cell type	Up	Down	Upregulated gene	∆	Downregulated gene	∆	PMID/GEO ID
IFN-γ stimulation		EC	2	2	NR2F1	1.39	NR2B1	−1.26	19553003/GSE3920
IFN-γ stimulation					NR3C1	1.53	NR2F6	−1.36	19553003/GSE3920
IL-1β stimulation		EC	3	7	NR1H4	5.32	NR1B2	−3.84	21469100/GSE19240
					NR3A1	2.21	NR1B3	−4.93
					NR5A2	6.57	NR1F1	−4.72
							NR1F2	−2.58
							NR3A2	−4.94
							NR3B3	−11.03
							NR4A1	−3.43
Human PBMCs-IL-1β and TNF-α stimulations	IL-1β 2 h	PBMC	0	3			NR1A1	−14.93	23104095/GSE40838
							NR1I1	−5.1
							NR3A2	−6.54
	IL-1β 6 h		0	1			NR5A2	−23.26
	TNF-α 2 h		1	1	NR1B2	38.32	NR2A1	−21.11
	TNF-α 6 h		2	3	NR1B2	27.28	NR1A2	−23.92
					NR3B3	4.92	NR1B3	−16.22
							NR4A1	−3.86

Abbreviations: IFN-γ interferon gamma, IL-1β interleukin-1β, TNF-α tumor necrosis factor-α-like, PBMCs peripheral blood mononuclear cells

ISSN: 1756-8722