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Table 16 Pro-inflammatory cytokine signaling negatively regulates the expression of nuclear receptors

From: A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors

Disease Tissue/cell type Number Upregulated gene Fold* Downregulated gene Fold* PMID/GEO ID
Up Down
IFN-γ stimulation EC 2 2 NR2F1 1.39 NR2B1 −1.26 19553003/GSE3920
    NR3C1 1.53 NR2F6 −1.36
IL-1β stimulation EC 3 7 NR1H4 5.32 NR1B2 −3.84 21469100/GSE19240
NR3A1 2.21 NR1B3 −4.93
NR5A2 6.57 NR1F1 −4.72
   NR1F2 −2.58
   NR3A2 −4.94
   NR3B3 −11.03
   NR4A1 −3.43
Human PBMCs-IL-1β and TNF-α stimulations IL-1β 2 h PBMC 0 3    NR1A1 −14.93 23104095/GSE40838
   NR1I1 −5.1
   NR3A2 −6.54
IL-1β 6 h 0 1    NR5A2 −23.26
TNF-α 2 h 1 1 NR1B2 38.32 NR2A1 −21.11
TNF-α 6 h 2 3 NR1B2 27.28 NR1A2 −23.92
NR3B3 4.92 NR1B3 −16.22
   NR4A1 −3.86
  1. Abbreviations: IFN-γ interferon gamma, IL-1β interleukin-1β, TNF-α tumor necrosis factor-α-like, PBMCs peripheral blood mononuclear cells