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Table 17 Anti-inflammatory cytokine signaling and Tregs positively regulate the expression of nuclear receptors

From: A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors

Disease

Tissue/cell type

Number

Upregulated gene

Fold*

Downregulated gene

Fold*

PMID/GEO ID

Up

Down

∆

∆

TGF-β stimulation

HCC Huh-7 cells

8

7

NR1B1

1.19

NR1B2

−1.21

19723656/GSE10393

NR1H2

1.37

NR1C3

−1.23

NR2B1

1.75

NR1D2

−1.35

NR2B2

1.23

NR1F1

−1.42

NR2F1

1.27

NR1H4

−1.45

NR2F2

1.36

NR3C1

−1.21

NR2F6

1.37

NR5A2

−1.29

NR0B2

1.59

  

TGF-β KO

PM cells

2

3

NR2C2

1.21

NR2C1

−1.26

23975680/GSE46150

NR3C1

1.23

NR2F6

−1.3

  

NR3C4

−1.67

Tconv stimulate by anti-CTLA-4

Spleen and lymph node

7

3

NR1D2

1.69

NR1B3

−1.14

23277554/GSE42267

NR1H3

1.2

NR2B1

−1.18

NR2C2

1.23

NR2C1

−1.28

NR3C4

1.64

  

NR4A1

5.61

  

NR4A2

15.78

  

NR4A3

8.12

  

Treg stimulated with anti-CTLA-4

Spleen and lymph node

5

4

NR1D2

1.53

NR1B1

−1.25

23277554/GSE42267

NR1F1

2.4

NR1B3

−1.32

NR3C4

2.36

NR1F1

−1.23

NR4A1

3.3

NR3A1

−1.23

NR4A2

6.67

  

Cardiac-specific transgenic (Tg-PPARα) mice

Heart

5

13

NR1F2

1.22

NR1A1

−1.27

22055503/GSE33101

NR1H3

1.46

NR1C1

−1.67

NR1I2

0.83

NR1F1

−3.84

NR2A1

1.24

NR1F3

−2

NR0B2

 

NR2B1

−1.22

  

NR2B2

−1.22

  

NR2B3

−1.59

  

NR2F2

−1.22

  

NR2F6

−1.27

  

NR3B1

−1.22

  

NR3B2

−1.23

  

NR3C1

−1.25

  

NR3C3

−1.27

NFκB inhibitor

4 h

EKC

6

5

NR1B1

2.33

NR1C2

−2.81

15722350/GSE2489

NR1B2

6.73

NR1F1

−6.54

NR1D1

3.36

NR1I3

−2.93

NR2A2

3.16

NR3A2

−2.91

NR2C1

2.01

NR5A2

−5.17

NR4A1

8.34

  

48 h

4

4

NR1H4

2.71

NR1C3

−5.46

NR2C1

5.35

NR2A1

−3.63

NR3A2

4.2

NR2F1

−14.03

NR4A3

4.56

NR3B3

−4.82

  1. Abbreviations: HCC hepatocellular carcinoma cells, TGF-β transforming growth factor-β, PM palatal mesenchyme, Tconv conventional T cells, Treg regulatory T cell, EKC epidermal keratinocytes