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Table 17 Anti-inflammatory cytokine signaling and Tregs positively regulate the expression of nuclear receptors

From: A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors

Disease Tissue/cell type Number Upregulated gene Fold* Downregulated gene Fold* PMID/GEO ID
Up Down
TGF-β stimulation HCC Huh-7 cells 8 7 NR1B1 1.19 NR1B2 −1.21 19723656/GSE10393
NR1H2 1.37 NR1C3 −1.23
NR2B1 1.75 NR1D2 −1.35
NR2B2 1.23 NR1F1 −1.42
NR2F1 1.27 NR1H4 −1.45
NR2F2 1.36 NR3C1 −1.21
NR2F6 1.37 NR5A2 −1.29
NR0B2 1.59   
TGF-β KO PM cells 2 3 NR2C2 1.21 NR2C1 −1.26 23975680/GSE46150
NR3C1 1.23 NR2F6 −1.3
   NR3C4 −1.67
Tconv stimulate by anti-CTLA-4 Spleen and lymph node 7 3 NR1D2 1.69 NR1B3 −1.14 23277554/GSE42267
NR1H3 1.2 NR2B1 −1.18
NR2C2 1.23 NR2C1 −1.28
NR3C4 1.64   
NR4A1 5.61   
NR4A2 15.78   
NR4A3 8.12   
Treg stimulated with anti-CTLA-4 Spleen and lymph node 5 4 NR1D2 1.53 NR1B1 −1.25 23277554/GSE42267
NR1F1 2.4 NR1B3 −1.32
NR3C4 2.36 NR1F1 −1.23
NR4A1 3.3 NR3A1 −1.23
NR4A2 6.67   
Cardiac-specific transgenic (Tg-PPARα) mice Heart 5 13 NR1F2 1.22 NR1A1 −1.27 22055503/GSE33101
NR1H3 1.46 NR1C1 −1.67
NR1I2 0.83 NR1F1 −3.84
NR2A1 1.24 NR1F3 −2
NR0B2   NR2B1 −1.22
   NR2B2 −1.22
   NR2B3 −1.59
   NR2F2 −1.22
   NR2F6 −1.27
   NR3B1 −1.22
   NR3B2 −1.23
   NR3C1 −1.25
   NR3C3 −1.27
NFκB inhibitor 4 h EKC 6 5 NR1B1 2.33 NR1C2 −2.81 15722350/GSE2489
NR1B2 6.73 NR1F1 −6.54
NR1D1 3.36 NR1I3 −2.93
NR2A2 3.16 NR3A2 −2.91
NR2C1 2.01 NR5A2 −5.17
NR4A1 8.34   
48 h 4 4 NR1H4 2.71 NR1C3 −5.46
NR2C1 5.35 NR2A1 −3.63
NR3A2 4.2 NR2F1 −14.03
NR4A3 4.56 NR3B3 −4.82
  1. Abbreviations: HCC hepatocellular carcinoma cells, TGF-β transforming growth factor-β, PM palatal mesenchyme, Tconv conventional T cells, Treg regulatory T cell, EKC epidermal keratinocytes