A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors

Table 17 Anti-inflammatory cytokine signaling and Tregs positively regulate the expression of nuclear receptors

Disease		Tissue/cell type	Number		Upregulated gene	Fold*	Downregulated gene	Fold*	PMID/GEO ID
Disease		Tissue/cell type	Up	Down	Upregulated gene	∆	Downregulated gene	∆	PMID/GEO ID
TGF-β stimulation		HCC Huh-7 cells	8	7	NR1B1	1.19	NR1B2	−1.21	19723656/GSE10393
					NR1H2	1.37	NR1C3	−1.23
					NR2B1	1.75	NR1D2	−1.35
					NR2B2	1.23	NR1F1	−1.42
					NR2F1	1.27	NR1H4	−1.45
					NR2F2	1.36	NR3C1	−1.21
					NR2F6	1.37	NR5A2	−1.29
					NR0B2	1.59
TGF-β KO		PM cells	2	3	NR2C2	1.21	NR2C1	−1.26	23975680/GSE46150
					NR3C1	1.23	NR2F6	−1.3
							NR3C4	−1.67
Tconv stimulate by anti-CTLA-4		Spleen and lymph node	7	3	NR1D2	1.69	NR1B3	−1.14	23277554/GSE42267
					NR1H3	1.2	NR2B1	−1.18
					NR2C2	1.23	NR2C1	−1.28
					NR3C4	1.64
					NR4A1	5.61
					NR4A2	15.78
					NR4A3	8.12
Treg stimulated with anti-CTLA-4		Spleen and lymph node	5	4	NR1D2	1.53	NR1B1	−1.25	23277554/GSE42267
					NR1F1	2.4	NR1B3	−1.32
					NR3C4	2.36	NR1F1	−1.23
					NR4A1	3.3	NR3A1	−1.23
					NR4A2	6.67
Cardiac-specific transgenic (Tg-PPARα) mice		Heart	5	13	NR1F2	1.22	NR1A1	−1.27	22055503/GSE33101
					NR1H3	1.46	NR1C1	−1.67
					NR1I2	0.83	NR1F1	−3.84
					NR2A1	1.24	NR1F3	−2
					NR0B2		NR2B1	−1.22
							NR2B2	−1.22
							NR2B3	−1.59
							NR2F2	−1.22
							NR2F6	−1.27
							NR3B1	−1.22
							NR3B2	−1.23
							NR3C1	−1.25
							NR3C3	−1.27
NFκB inhibitor	4 h	EKC	6	5	NR1B1	2.33	NR1C2	−2.81	15722350/GSE2489
					NR1B2	6.73	NR1F1	−6.54
					NR1D1	3.36	NR1I3	−2.93
					NR2A2	3.16	NR3A2	−2.91
					NR2C1	2.01	NR5A2	−5.17
					NR4A1	8.34
	48 h		4	4	NR1H4	2.71	NR1C3	−5.46
					NR2C1	5.35	NR2A1	−3.63
					NR3A2	4.2	NR2F1	−14.03
					NR4A3	4.56	NR3B3	−4.82

Abbreviations: HCC hepatocellular carcinoma cells, TGF-β transforming growth factor-β, PM palatal mesenchyme, Tconv conventional T cells, Treg regulatory T cell, EKC epidermal keratinocytes

ISSN: 1756-8722