|
1. Five domain structures including N-terminal regulatory domain, DNA binding domain, hinge region, ligand-binding domain, and C-terminal domain
|
10406480/10751636/12893880
|
|
2. Lipophilic ligand-activated transcription factors including orphan receptors for unknown endogenous ligands
|
8,807,884/10671476
|
|
3. 48 known super human family members including seven groups, mice (49), rats (47), C. elephant (270)
|
10219237/9460643/15059999
|
|
4. 350 co-regulators to facilitate their functions
|
22733267
|
|
5. Transduce steroid, thyroid, retinoid, and other hormonal signals
|
11729302/8521507
|
|
6. Metabolic sensors and xenobiotic sensors for high-affinity ligands and low-affinity molecular patterns
|
20615454
|
|
7. Serve as the targets for 13% FDA-approved drugs
|
17139284
|
