Table 2 The common features of nuclear receptors
Common features of nuclear receptors | PMID |
|---|---|
1. Five domain structures including N-terminal regulatory domain, DNA binding domain, hinge region, ligand-binding domain, and C-terminal domain | 10406480/10751636/12893880 |
2. Lipophilic ligand-activated transcription factors including orphan receptors for unknown endogenous ligands | 8,807,884/10671476 |
3. 48 known super human family members including seven groups, mice (49), rats (47), C. elephant (270) | 10219237/9460643/15059999 |
4. 350 co-regulators to facilitate their functions | 22733267 |
5. Transduce steroid, thyroid, retinoid, and other hormonal signals | 11729302/8521507 |
6. Metabolic sensors and xenobiotic sensors for high-affinity ligands and low-affinity molecular patterns | 20615454 |
7. Serve as the targets for 13% FDA-approved drugs | 17139284 |