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Table 20 Nuclear receptors are significantly changed in caspase-1 and Sirt1 knockout mice, indicating that caspase-1-Sirt1 pathway negatively regulates nuclear receptor expression

From: A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors

Disease Tissue/cell type Number Upregulated gene Fold* Downregulated gene Fold* PMID/GEO ID
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AopE−/−/Casp1−/− vs. ApoE−/− Aorta 3 0 NR1A2 1.22    GSE72448
NR1D2 1.17   
NR2C2 1.19   
Adipose 10 1 NR1A1 1.35 NR6A1 −1.32
NR1C3 1.84   
NR1F1 1.78   
NR1I3 1.22   
NR2A1 2.24   
NR2B1 1.52   
NR3A1 1.39   
NR3C1 1.41   
NR3C4 1.66   
NR4A2 1.16   
Casp1−/−/ASC−/− vs. ASC−/− White adipose tissue 7 0 NR1A1 1.35    21876127/GSE25205
NR1C3 1.84   
NR1I3 1.22   
NR2A1 1.17   
NR2B1 1.52   
NR3C4 1.65   
NR4A2 1.16   
Sirt1−/− vs. WT Treg 4 0 NR1B1 1.2    21199917/GSE26425
NR1F1 1.29   
NR2F6 1.22   
NR4A3 1.29   
Cardiac-specific transgenic (Tg-Sirt1) mice Heart 2 6 NR3C4 1.52 NR1B1 −3.57 22055503/GSE33101
NR0B2 1.35 NR1B3 −1.25
   NR1F3 −2
   NR1I1 −1.27
   NR2B3 −1.22
   NR2C1 −1.22
NLRP3 mutation Adult control PBMC 26 9 NR1B1 1.22 NR1F1 −2.93 –/GSE43553
NR1B2 1.47 NR1F2 −1.4
NR1B3 1.43 NR2C1 −1.93
NR1C2 1.18 NR3C1 −1.38
NR1C3 1.2 NR3C2 −1.68
NR1I1 1.73 NR4A1 −1.32
NR1I2 1.2   
NR2A1 1.53   
NR2B3 1.25   
NR2E1 1.31   
NR2E3 1.57   
NR2F1 1.2   
NR3A1 1.61   
NR3A2 1.28   
NR3B1 1.34   
NR4A3 1.27   
NR5A1 1.42   
NR6A1 1.3   
NR0B2 1.34   
Children control 26 11 NR1A1 1.4 NR1D1 −1.82
NR1A2 1.24 NR1D2 −1.56
NR1B1 1.31 NR1F1 −2.53
NR1B2 1.51 NR2B2 −1.44
NR1B3 1.49 NR2C1 −2.25
NR1C3 1.32 NR2C2 −1.29
NR1I1 1.69 NR3C1 −1.3
NR1I2 1.27 NR3C2 −1.53
NR2A1 1.66 NR4A1 −1.37
NR2A2 1.22 NR4A2 −4.23
NR2E1 1.21   
NR2E3 1.55   
NR2F1 1.24   
NR2F6 1.26   
NR3A1 1.23   
NR3A2 1.41   
NR3B1 1.65   
NR3C3 1.21   
NR4A3 1.23   
NR5A1 1.41   
NR6A1 1.29   
NR0B2 1.34   
  1. Abbreviations: ApoE−/− apolipoprotein E-deficient mice, Casp1−/− caspase-1-deficient mice, HFD high fat diet, ASC−/− PYD and CARD domain-containing deficient mice, Sirt 1−/− sirtuin 1-deficient mice; WT wild-type mice, NLRP3 NLR family pyrin domain containing 3 deficient mice; vs. versus