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1. Ligand-binding domains have the capacity to bind coactivator segments with LXXLL sequences, and corepressor segments with LXXXLXXX[I/L] sequences (where L = leucine, I = isoleucine, and X = any amino acid)
|
9808622
|
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2. A single nuclear receptor controls the multitude of gene expressions
|
20148675
|
|
3. The ligand-binding domain consists of a hydrophobic pocket that can bind a hydrophobic ligand
|
20615454
|
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4. Flexible ligands can contort to fit in the ligand-binding pocket
|
9501913
|
|
5. Pharmacological antagonists and have been shown to bind to the receptor in the ligand-binding site and to inhibit hormone-activated receptor function
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(1). NR1A1 ligand-binding domain can bind 3,5-dimethyl-3-isopropylthyronine except thyroid hormone
|
8523397
|
|
(2). NR1B3 ligand-binding domain can bind to all-trans retinoic acid except vitamin A and related compounds
|
7501014
|
|
(3). NR3A1 ligand-binding domain can bind to estradiol and raloxifene
|
9338790
|
