Skip to main content

Table 3 Nuclear receptors can recognize and bind many ligands which have similar structures/patterns via its ligand-binding domain

From: A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors

Features of nuclear receptors’ ligand-binding domain PMID
1. Ligand-binding domains have the capacity to bind coactivator segments with LXXLL sequences, and corepressor segments with LXXXLXXX[I/L] sequences (where L = leucine, I = isoleucine, and X = any amino acid) 9808622
2. A single nuclear receptor controls the multitude of gene expressions 20148675
3. The ligand-binding domain consists of a hydrophobic pocket that can bind a hydrophobic ligand 20615454
4. Flexible ligands can contort to fit in the ligand-binding pocket 9501913
5. Pharmacological antagonists and have been shown to bind to the receptor in the ligand-binding site and to inhibit hormone-activated receptor function  
(1). NR1A1 ligand-binding domain can bind 3,5-dimethyl-3-isopropylthyronine except thyroid hormone 8523397
(2). NR1B3 ligand-binding domain can bind to all-trans retinoic acid except vitamin A and related compounds 7501014
(3). NR3A1 ligand-binding domain can bind to estradiol and raloxifene 9338790