A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors

Table 4 28 out of 43 nuclear receptors in classes I–IV are highly expressed in the human muscle, trachea, nerve, and other tissues

Gene	Human tissues
Gene	Adipose tissue	Adrenal gland	Brain	Eye	Heart	Intestine	Kidney	Liver	Lymph node	Muscle	Nerve	Pancreas	Skin	Spleen	Stomach	Trachea
Class I—thyroid hormone receptor-like (15 out of 19)
THRA			*	*	*					*	*
THRB										*						*
RARA																*
RARB				*			*	*								*
RARG																*
PPARA		*					*	*		*	*
PPARD											*					*
PPARG	*					*					*
NR1D1				*						*	*	*				*
NR1D2				*						*
RORA		*								*			*
RORC		*				*	*	*	*	*						*
NR1H3	*				*					*				*
NR1H2										*
VDR																*
Class II—retinoid X receptor-like (5 out of 12)
RXRA										*
RXRB																*
NR2C2									*	*						*
NR2F2	*			*						*	*	*
NR2F6				*
Class III—estrogen receptor-like (5 out of 9)
ESR1		*								*						*
ESRRA							*		*	*		*
NR3C2				*	*					*					*	*
PGR					*		*	*		*	*
AR											*	*				*
Class IV—nerve growth factor IB-like (3 out of 3)
NR4A1	*
NR4A2		*	*								*					*
NR4A3	*	*								*	*

ISSN: 1756-8722