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Table 7 Several findings in this study are significantly novel in comparing to what is published

From: A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors

Items

Expression profile of Nuclear receptors

Our findings

Cell paper (PMID: 16923397)

The number of nuclear receptors

48 known human NR

49 known mouse NR

Species

Human and mouse

Mouse

The number of tissues

21 human tissues and 17 mouse tissues

Only 39 mouse tissues

Analysis method

cDNA cloning and DNA sequencing experiments (EST database)

RT-PCR (high-throughput capacity)

Advantage of the method

More precise

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NR groups based on their tissue distribution

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Restricted (11), widespread (17), all tissues (21)

NR groups based on the expression level of nuclear receptors

Super high (12), high (5), low (3), super low activation (28)

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Tissue groups based on number of highly expressed nuclear receptors

Super high (3/2 in human/mouse), high (4/5 in human/mouse), low (3/5 in human/mouse), supper low varieties (6/2 in human/mouse)

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CNS (# human/mouse)

Brain, eye, nerve (19/1)

Eye, brainstem, cerebellum, cerebrum, corpus striatum, olfactory bulb, spinal cord, hypothalamus, and pituitary (11)

Gastroenteric system (# human/mouse)

Stomach, pancreas (5/5)

Tongue, stomach, duodenum, jejunum, ileum, colon, and gall bladder (13)

Metabolic system (# human/mouse)

Liver, kidney, adrenal gland, adipose, intestine, and muscle (40/14)

Liver, kidney, brown and white adipose, and muscle (13)

Immune system (# human/mouse)

Spleen and lymph node (4/6)

Spleen and thymus (2)

Cardiovascular system (# human/mouse)

Heart, lung, blood and trachea (19/6)

Aorta, heart, and lung (8)

Structural system (# human/mouse)

Skin (1/7)

Bone and skin (5)