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Table 8 45 out of 48 nuclear receptors with sequence changes or mutations are associated with increased risks of human rheumatoid arthritis, obese, diabetes, and metabolic vascular diseases

From: A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors

Gene

Diseases

Rheumatoid arthritis

Obese

Diabetes

Vascular dis. and atherosclerosis

Phenotype ID (HGVPM)

Phenotype ID (HGVPM)

Phenotype ID (HGVPM)

Phenotype ID (HGVPM)

38

235

564

1111

1114

4

5

74

822

825

826

827

569

769

1081

1538

3639

563

568

3602

3611

3640

3616

THRA

*

*

*

*

*

*

*

 

*

*

*

*

*

*

*

  

*

*

    

THRB

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

*

 

*

*

    

RARA

*

 

*

*

*

*

  

*

*

*

*

*

*

*

*

 

*

*

    

RARB

*

 

*

*

    

*

*

*

*

*

 

*

*

       

RARG

   

*

*

   

*

*

*

*

 

*

*

*

       

PPARA

*

*

*

*

*

*

*

 

*

*

*

*

*

*

*

*

 

*

*

*

*

*

 

PPARD

*

*

*

*

*

*

*

 

*

*

*

*

*

*

*

*

 

*

*

    

PPARG

  

*

*

*

 

*

 

*

*

*

*

*

*

*

*

 

*

*

    

NR1D1

  

*

*

*

   

*

*

*

*

*

 

*

*

 

*

*

    

NR1D2

*

*

*

*

*

*

*

 

*

*

*

*

*

*

*

*

 

*

*

    

RORA

*

*

*

*

*

*

*

 

*

*

*

*

*

*

*

*

*

*

*

    

RORB

*

*

*

*

*

*

*

 

*

*

*

*

*

*

*

*

 

*

*

    

RORC

*

*

*

*

*

*

  

*

*

*

*

*

*

*

*

 

*

*

    

NR1H3

*

*

*

*

*

*

*

 

*

*

*

*

*

*

*

*

 

*

*

    

NR1H2

   

*

*

   

*

*

*

*

  

*

*

       

NR1H4

*

*

*

*

 

*

*

 

*

*

*

*

*

*

*

*

 

*

*

    

VDR

*

*

*

*

    

*

*

*

*

*

 

*

*

       

NR1I2

*

*

*

*

 

*

*

 

*

*

*

*

*

*

*

*

 

*

*

    

NR1I3

*

*

*

*

*

*

  

*

*

*

*

*

*

*

*

 

*

*

    

HNF4A

*

*

*

*

    

*

*

*

*

*

 

*

*

  

*

    

HNF4G

*

*

*

*

*

*

*

 

*

*

*

*

*

*

*

*

 

*

*

    

RXRA

*

*

*

*

 

*

*

 

*

*

*

*

*

*

*

*

 

*

*

    

RXRG

*

*

*

*

*

*

*

 

*

*

*

*

*

*

*

*

 

*

*

    

NR2C1

*

*

*

*

*

*

*

 

*

*

*

*

*

*

*

*

 

*

*

    

NR2C2

*

*

*

*

*

*

*

 

*

*

*

*

*

*

*

*

 

*

*

    

NR2E1

*

*

*

*

*

*

*

 

*

*

*

*

*

*

*

*

 

*

*

    

NR2E3

   

*

*

   

*

*

*

*

 

*

*

*

       

NR2F1

*

*

*

*

*

*

  

*

*

*

*

*

*

*

*

 

*

*

    

NR2F2

      

*

                

NR2F6

   

*

*

   

*

*

*

*

 

*

*

*

       

ESR1

*

*

*

*

*

*

*

 

*

*

*

*

*

*

*

*

 

*

*

    

ESR2

*

*

*

*

*

*

*

 

*

*

*

*

*

*

*

*

 

*

*

    

ESRRA

    

*

   

*

*

*

*

 

*

*

        

ESRRB

*

*

*

*

*

*

*

 

*

*

*

*

*

*

*

*

 

*

*

    

ESRRG

*

*

*

*

*

*

*

 

*

*

*

*

*

*

*

*

 

*

*

    

NR3C1

*

*

*

*

*

*

*

 

*

*

*

*

*

*

*

*

 

*

*

    

NR3C2

*

*

*

*

*

*

*

 

*

*

*

*

*

*

*

*

 

*

*

*

*

*

*

PGR

*

*

*

*

*

*

*

 

*

*

*

*

*

*

*

*

 

*

*

    

AR

*

*

*

   

*

     

*

    

*

*

    

NR4A1

*

*

*

*

*

*

*

 

*

*

*

*

*

*

*

*

 

*

*

    

NR4A2

*

*

*

*

*

*

*

 

*

*

*

*

*

*

*

*

 

*

*

    

NR4A3

*

*

*

*

*

*

*

 

*

*

*

*

*

*

*

*

 

*

*

    

NR5A1

*

*

*

*

*

*

  

*

*

*

*

*

*

*

*

 

*

*

    

NR5A2

*

*

*

*

*

*

*

 

*

*

*

*

*

*

*

*

 

*

*

    

NR6A1

*

*

*

*

*

*

*

 

*

*

*

*

*

*

*

*

 

*

*

    
  1. Nuclear receptors marked with bold have a pro-inflammatory role