A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors

Table 8 45 out of 48 nuclear receptors with sequence changes or mutations are associated with increased risks of human rheumatoid arthritis, obese, diabetes, and metabolic vascular diseases

Gene	Diseases
	Rheumatoid arthritis		Obese			Diabetes												Vascular dis. and atherosclerosis
	Phenotype ID (HGVPM)		Phenotype ID (HGVPM)			Phenotype ID (HGVPM)												Phenotype ID (HGVPM)
	38	235	564	1111	1114	4	5	74	822	825	826	827	569	769	1081	1538	3639	563	568	3602	3611	3640	3616
THRA	*	*	*	*	*	*	*		*	*	*	*	*	*	*			*	*
THRB	*	*	*	*	*	*	*	*	*	*	*	*	*	*	*	*		*	*
RARA	*		*	*	*	*			*	*	*	*	*	*	*	*		*	*
RARB	*		*	*					*	*	*	*	*		*	*
RARG				*	*				*	*	*	*		*	*	*
PPARA	*	*	*	*	*	*	*		*	*	*	*	*	*	*	*		*	*	*	*	*
PPARD	*	*	*	*	*	*	*		*	*	*	*	*	*	*	*		*	*
PPARG			*	*	*		*		*	*	*	*	*	*	*	*		*	*
NR1D1			*	*	*				*	*	*	*	*		*	*		*	*
NR1D2	*	*	*	*	*	*	*		*	*	*	*	*	*	*	*		*	*
RORA	*	*	*	*	*	*	*		*	*	*	*	*	*	*	*	*	*	*
RORB	*	*	*	*	*	*	*		*	*	*	*	*	*	*	*		*	*
RORC	*	*	*	*	*	*			*	*	*	*	*	*	*	*		*	*
NR1H3	*	*	*	*	*	*	*		*	*	*	*	*	*	*	*		*	*
NR1H2				*	*				*	*	*	*			*	*
NR1H4	*	*	*	*		*	*		*	*	*	*	*	*	*	*		*	*
VDR	*	*	*	*					*	*	*	*	*		*	*
NR1I2	*	*	*	*		*	*		*	*	*	*	*	*	*	*		*	*
NR1I3	*	*	*	*	*	*			*	*	*	*	*	*	*	*		*	*
HNF4A	*	*	*	*					*	*	*	*	*		*	*			*
HNF4G	*	*	*	*	*	*	*		*	*	*	*	*	*	*	*		*	*
RXRA	*	*	*	*		*	*		*	*	*	*	*	*	*	*		*	*
RXRG	*	*	*	*	*	*	*		*	*	*	*	*	*	*	*		*	*
NR2C1	*	*	*	*	*	*	*		*	*	*	*	*	*	*	*		*	*
NR2C2	*	*	*	*	*	*	*		*	*	*	*	*	*	*	*		*	*
NR2E1	*	*	*	*	*	*	*		*	*	*	*	*	*	*	*		*	*
NR2E3				*	*				*	*	*	*		*	*	*
NR2F1	*	*	*	*	*	*			*	*	*	*	*	*	*	*		*	*
NR2F2							*
NR2F6				*	*				*	*	*	*		*	*	*
ESR1	*	*	*	*	*	*	*		*	*	*	*	*	*	*	*		*	*
ESR2	*	*	*	*	*	*	*		*	*	*	*	*	*	*	*		*	*
ESRRA					*				*	*	*	*		*	*
ESRRB	*	*	*	*	*	*	*		*	*	*	*	*	*	*	*		*	*
ESRRG	*	*	*	*	*	*	*		*	*	*	*	*	*	*	*		*	*
NR3C1	*	*	*	*	*	*	*		*	*	*	*	*	*	*	*		*	*
NR3C2	*	*	*	*	*	*	*		*	*	*	*	*	*	*	*		*	*	*	*	*	*
PGR	*	*	*	*	*	*	*		*	*	*	*	*	*	*	*		*	*
AR	*	*	*				*						*					*	*
NR4A1	*	*	*	*	*	*	*		*	*	*	*	*	*	*	*		*	*
NR4A2	*	*	*	*	*	*	*		*	*	*	*	*	*	*	*		*	*
NR4A3	*	*	*	*	*	*	*		*	*	*	*	*	*	*	*		*	*
NR5A1	*	*	*	*	*	*			*	*	*	*	*	*	*	*		*	*
NR5A2	*	*	*	*	*	*	*		*	*	*	*	*	*	*	*		*	*
NR6A1	*	*	*	*	*	*	*		*	*	*	*	*	*	*	*		*	*

ISSN: 1756-8722