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Table 8 45 out of 48 nuclear receptors with sequence changes or mutations are associated with increased risks of human rheumatoid arthritis, obese, diabetes, and metabolic vascular diseases

From: A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors

Gene Diseases
Rheumatoid arthritis Obese Diabetes Vascular dis. and atherosclerosis
Phenotype ID (HGVPM) Phenotype ID (HGVPM) Phenotype ID (HGVPM) Phenotype ID (HGVPM)
38 235 564 1111 1114 4 5 74 822 825 826 827 569 769 1081 1538 3639 563 568 3602 3611 3640 3616
THRA * * * * * * *   * * * * * * *    * *     
THRB * * * * * * * * * * * * * * * *   * *     
RARA *   * * * *    * * * * * * * *   * *     
RARB *   * *      * * * * *   * *        
RARG     * *     * * * *   * * *        
PPARA * * * * * * *   * * * * * * * *   * * * * *  
PPARD * * * * * * *   * * * * * * * *   * *     
PPARG    * * *   *   * * * * * * * *   * *     
NR1D1    * * *     * * * * *   * *   * *     
NR1D2 * * * * * * *   * * * * * * * *   * *     
RORA * * * * * * *   * * * * * * * * * * *     
RORB * * * * * * *   * * * * * * * *   * *     
RORC * * * * * *    * * * * * * * *   * *     
NR1H3 * * * * * * *   * * * * * * * *   * *     
NR1H2     * *     * * * *    * *        
NR1H4 * * * *   * *   * * * * * * * *   * *     
VDR * * * *      * * * * *   * *        
NR1I2 * * * *   * *   * * * * * * * *   * *     
NR1I3 * * * * * *    * * * * * * * *   * *     
HNF4A * * * *      * * * * *   * *    *     
HNF4G * * * * * * *   * * * * * * * *   * *     
RXRA * * * *   * *   * * * * * * * *   * *     
RXRG * * * * * * *   * * * * * * * *   * *     
NR2C1 * * * * * * *   * * * * * * * *   * *     
NR2C2 * * * * * * *   * * * * * * * *   * *     
NR2E1 * * * * * * *   * * * * * * * *   * *     
NR2E3     * *     * * * *   * * *        
NR2F1 * * * * * *    * * * * * * * *   * *     
NR2F2        *                 
NR2F6     * *     * * * *   * * *        
ESR1 * * * * * * *   * * * * * * * *   * *     
ESR2 * * * * * * *   * * * * * * * *   * *     
ESRRA      *     * * * *   * *         
ESRRB * * * * * * *   * * * * * * * *   * *     
ESRRG * * * * * * *   * * * * * * * *   * *     
NR3C1 * * * * * * *   * * * * * * * *   * *     
NR3C2 * * * * * * *   * * * * * * * *   * * * * * *
PGR * * * * * * *   * * * * * * * *   * *     
AR * * *     *       *      * *     
NR4A1 * * * * * * *   * * * * * * * *   * *     
NR4A2 * * * * * * *   * * * * * * * *   * *     
NR4A3 * * * * * * *   * * * * * * * *   * *     
NR5A1 * * * * * *    * * * * * * * *   * *     
NR5A2 * * * * * * *   * * * * * * * *   * *     
NR6A1 * * * * * * *   * * * * * * * *   * *     
  1. Nuclear receptors marked with bold have a pro-inflammatory role