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Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: Role of AP-2α and MAPK7 in the regulation of autocrine TGF-β/miR-200b signals to maintain epithelial-mesenchymal transition in cholangiocarcinoma

Fig. 2

Overexpression of miR-200b inhibits the TGF-β-induced EMT and tumor cell proliferation. a The expression of miR-200b was analyzed in TGF-β1-treated HCCC and BRE cells. After the transfection of miR-200b into HCCC and BRE cells, (b) the cell morphology was analyzed, (c) mRNA and protein expression of E-cadherin, TTF-1, fibronectin, and α-SMA was determined by Q-PCR and western blot. d Transwell assay was performed to determine migration and invasion. e HCCC and BRE cells were overexpressed with miR-200b, and the cell vitality was measured by CCK-8. *p < 0.05, **p < 0.01, ***p < 0.001, data represent the mean ± SD

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