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Fig. 3 | Journal of Hematology & Oncology

Fig. 3

From: Role of protein kinases CK1α and CK2 in multiple myeloma: regulation of pivotal survival and stress-managing pathways

Fig. 3

Schematic representation of the role of CK2 nutrients withdrawal. Upon nutrient withdrawal, CK2 phosphorylates Ser485 (S485) on Tel2 and Ser828 (S828) on Tt1, enabling the E3 ubiquitin ligase SCFFbxo9 to target Tel2 and Tt1. The mTORC1 complex is therefore disassembled, and its inhibitory effect on mTORC2 is subsequently removed, allowing the cell to maintain the survival state

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Journal of Hematology & Oncology

ISSN: 1756-8722

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