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Table 4 Clinical trials of CAR-T cells for solid tumors in China

From: Clinical trials of CAR-T cells in China

Target antigens

Diseases

CAR

Vector

NCT no.

GPC3

Hepatocellular carcinoma

NA

NA

NCT02723942

GPC3

Hepatocellular carcinoma

CD3ζ, CD28, and 4-1BB

NA

NCT02395250

GPC3

Lung squamous cell carcinoma

NA

LV

NCT02876978

GPC3

Hepatocellular carcinoma and liver metastases

4-1BB

NA

NCT02715362

GPC3

Hepatocellular carcinoma

4-1BB

NA

NCT03130712

GPC3

Advanced hepatocellular carcinoma

4-1BB-CD3ζ

RV

NCT03084380

GPC3

Hepatocellular carcinoma, squamous cell lung cancer

NA

NA

NCT03198546

GPC3

Hepatocellular carcinoma

NA

LV

NCT03146234

GPC3, mesothelin, CEA

Hepatocellular, pancreatic cancer, colorectal cancer

NA

LV

NCT02959151

Mesothelin

Malignant mesothelioma, pancreatic Cancer, ovarian tumor, triple-negative breast cancer, endometrial cancer, other mesothelin-positive tumors

4-1BB-CD3ζ

RV

NCT02580747

Mesothelin

Recurrent or metastatic malignant tumors

NA

NA

NCT02930993

Mesothelin

Pancreatic cancer and pancreatic ductal a denocarcinoma

4-1BB

NA

NCT02706782

Mesothelin

Solid tumor, adult advanced cancer

NA

NA

NCT03030001

Mesothelin

Advanced solid tumor

NA

NA

NCT03182803

EpCAM

Liver neoplasms

NA

NA

NCT02729493

EpCAM

Stomach neoplasms

NA

NA

NCT02725125

EpCAM

Nasopharyngeal carcinoma and breast cancer

NA

LV

NCT02915445

EpCAM

Colon cancer, esophageal carcinoma, pancreatic cancer, prostate cancer, gastric cancer, hepatic carcinoma

CD3ζ, CD28

LV

NCT03013712

GD2

Neuroblastoma

NA

LV

NCT02765243

GD2

Relapsed or refractory neuroblastoma

NA

NA

NCT02919046

GD2

Solid tumor

NA

LV

NCT02992210

HER-2

Advanced HER-2-positive solid tumors

CD3ζ, 4-1BB-CD3ζ

NA

NCT01935843

HER-2

Breast cancer

CD28-CD3ζ

RV

NCT02547961

HER-2

Breast cancer, ovarian cancer, lung cancer, gastric cancer, glioma, pancreatic cancer

NA

NA

NCT02713984

EGFR

Advanced EGFR-positive solid tumors

4-1BB-CD3ζ

LV

NCT01869166

EGFR

Advanced solid tumor

NA

NA

NCT03182816

EGFR

Colorectal cancer

4-1BB-CD28-CD3

NA

NCT03152435

EGFRvIII

Recurrent glioblastoma multiform

NA

LV

NCT02844062

EGFRvIII

Glioblastoma multiform

NA

NA

NCT03170141

MUC1

Malignant glioma of brain, colorectal carcinoma, gastric carcinoma

NA

NA

NCT02617134

MUC1

Advanced refractory solid tumor (hepatocellular carcinoma, NSCLC, pancreatic carcinoma, triple-negative invasive breast carcinoma)

CD28-4-1BB- CD3ζ

LV

NCT02587689

MUC1

Advanced solid tumor

NA

NA

NCT03179007

CEA

Lung cancer, colorectal cancer, gastric cancer, breast cancer, pancreatic cancer

NA

NA

NCT02349724

EphA2

EphA2-positive malignant glioma

NA

NA

NCT02575261

LMP1

Nasopharyngeal neoplasms

NA

NA

NCT02980315

MG7

Liver metastases

4-1BB

NA

NCT02862704

CD133

Liver cancer, pancreatic cancer, brain tumor, breast cancer, ovarian tumor, colorectal cancer, ALL, AML

CD3ζ, 4-1BB-CD3ζ

RV

NCT02541370

HerinCAR-PD1

Advanced malignancies

NA

NA

NCT02873390

HerinCAR-PD1

Advanced solid tumor (lung, liver, and stomach)

NA

NA

NCT02862028

PD-L1 CSR

Glioblastoma multiform

NA

NA

NCT02937844

NY-ESO-1

Advanced NSCLC

NA

LV

NCT03029273

Zeushield

NSCLC

NA

NA

NCT03060343

PSCA/MUC1/PD-L1/CD80/86

Advanced lung or other cancers

NA

NA

NCT03198052

PSMA, FRa

Bladder cancer, urothelial carcinoma bladder

NA

NA

NCT03185468

Claudin18.2

Advanced gastric adenocarcinoma, pancreatic adenocarcinoma

NA

LV

NCT03159819

  1. CTX cyclophosphamide, FLU fludarabine, LV lentiviral, NA not available, NSCLC non-small cell lung cancer, RV retroviral