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Table 4 Clinical trials of CAR-T cells for solid tumors in China

From: Clinical trials of CAR-T cells in China

Target antigens Diseases CAR Vector NCT no.
GPC3 Hepatocellular carcinoma NA NA NCT02723942
GPC3 Hepatocellular carcinoma CD3ζ, CD28, and 4-1BB NA NCT02395250
GPC3 Lung squamous cell carcinoma NA LV NCT02876978
GPC3 Hepatocellular carcinoma and liver metastases 4-1BB NA NCT02715362
GPC3 Hepatocellular carcinoma 4-1BB NA NCT03130712
GPC3 Advanced hepatocellular carcinoma 4-1BB-CD3ζ RV NCT03084380
GPC3 Hepatocellular carcinoma, squamous cell lung cancer NA NA NCT03198546
GPC3 Hepatocellular carcinoma NA LV NCT03146234
GPC3, mesothelin, CEA Hepatocellular, pancreatic cancer, colorectal cancer NA LV NCT02959151
Mesothelin Malignant mesothelioma, pancreatic Cancer, ovarian tumor, triple-negative breast cancer, endometrial cancer, other mesothelin-positive tumors 4-1BB-CD3ζ RV NCT02580747
Mesothelin Recurrent or metastatic malignant tumors NA NA NCT02930993
Mesothelin Pancreatic cancer and pancreatic ductal a denocarcinoma 4-1BB NA NCT02706782
Mesothelin Solid tumor, adult advanced cancer NA NA NCT03030001
Mesothelin Advanced solid tumor NA NA NCT03182803
EpCAM Liver neoplasms NA NA NCT02729493
EpCAM Stomach neoplasms NA NA NCT02725125
EpCAM Nasopharyngeal carcinoma and breast cancer NA LV NCT02915445
EpCAM Colon cancer, esophageal carcinoma, pancreatic cancer, prostate cancer, gastric cancer, hepatic carcinoma CD3ζ, CD28 LV NCT03013712
GD2 Neuroblastoma NA LV NCT02765243
GD2 Relapsed or refractory neuroblastoma NA NA NCT02919046
GD2 Solid tumor NA LV NCT02992210
HER-2 Advanced HER-2-positive solid tumors CD3ζ, 4-1BB-CD3ζ NA NCT01935843
HER-2 Breast cancer CD28-CD3ζ RV NCT02547961
HER-2 Breast cancer, ovarian cancer, lung cancer, gastric cancer, glioma, pancreatic cancer NA NA NCT02713984
EGFR Advanced EGFR-positive solid tumors 4-1BB-CD3ζ LV NCT01869166
EGFR Advanced solid tumor NA NA NCT03182816
EGFR Colorectal cancer 4-1BB-CD28-CD3 NA NCT03152435
EGFRvIII Recurrent glioblastoma multiform NA LV NCT02844062
EGFRvIII Glioblastoma multiform NA NA NCT03170141
MUC1 Malignant glioma of brain, colorectal carcinoma, gastric carcinoma NA NA NCT02617134
MUC1 Advanced refractory solid tumor (hepatocellular carcinoma, NSCLC, pancreatic carcinoma, triple-negative invasive breast carcinoma) CD28-4-1BB- CD3ζ LV NCT02587689
MUC1 Advanced solid tumor NA NA NCT03179007
CEA Lung cancer, colorectal cancer, gastric cancer, breast cancer, pancreatic cancer NA NA NCT02349724
EphA2 EphA2-positive malignant glioma NA NA NCT02575261
LMP1 Nasopharyngeal neoplasms NA NA NCT02980315
MG7 Liver metastases 4-1BB NA NCT02862704
CD133 Liver cancer, pancreatic cancer, brain tumor, breast cancer, ovarian tumor, colorectal cancer, ALL, AML CD3ζ, 4-1BB-CD3ζ RV NCT02541370
HerinCAR-PD1 Advanced malignancies NA NA NCT02873390
HerinCAR-PD1 Advanced solid tumor (lung, liver, and stomach) NA NA NCT02862028
PD-L1 CSR Glioblastoma multiform NA NA NCT02937844
NY-ESO-1 Advanced NSCLC NA LV NCT03029273
Zeushield NSCLC NA NA NCT03060343
PSCA/MUC1/PD-L1/CD80/86 Advanced lung or other cancers NA NA NCT03198052
PSMA, FRa Bladder cancer, urothelial carcinoma bladder NA NA NCT03185468
Claudin18.2 Advanced gastric adenocarcinoma, pancreatic adenocarcinoma NA LV NCT03159819
  1. CTX cyclophosphamide, FLU fludarabine, LV lentiviral, NA not available, NSCLC non-small cell lung cancer, RV retroviral