Table 5 Clinical trials of CAR-T cells with fourth-generation CARs in China
Target antigen | Disease | Vector | NCT no. |
|---|---|---|---|
CD19 | B cell malignancies | LV | NCT03050190 |
CD19 | B cell lymphomas | LV | NCT02247609 |
CD19 | B cell leukemia | LV | NCT02968472 |
CD19/CD22 | B cell leukemia, B cell lymphoma | LV | NCT03098355 |
CD19 and CD20/CD22/CD38/CD123 | B cell malignancy | LV | NCT03125577 |
CD30 | Lymphoma | LV | NCT02274584 |
PSMA, FRa | Bladder cancer, urothelial carcinoma bladder | NA | NCT03185468 |
EGFRvIII | Glioblastoma multiform | NA | NCT03170141 |
GD2 | Neuroblastoma | LV | NCT02765243 |
GD2 | Solid tumor | LV | NCT02992210 |