Table 5 Documented treatment-emergent all-grade adverse events in ≥ 10% of patients (safety population)
|  | L (n = 13) | L + R (n = 11) | L + other (n = 34) | Overall (N = 58) | ||||
|---|---|---|---|---|---|---|---|---|
No. | % | No. | % | No. | % | No. | % | |
Hematologic | ||||||||
 Anemia | 2 | 15 | 3 | 27 | 5 | 15 | 10 | 17 |
 Thrombocytopenia | 1 | 8 | 1 | 9 | 7 | 21 | 9 | 16 |
 Neutropenia | 1 | 8 | 1 | 9 | 6 | 18 | 8 | 14 |
 Pancytopenia | 1 | 8 | 3 | 27 | 3 | 9 | 7 | 12 |
 Febrile neutropenia | 0 | 0 | 0 | 0 | 6 | 18 | 6 | 10 |
Nonhematologic | ||||||||
 Fatigue | 4 | 31 | 4 | 36 | 14 | 41 | 22 | 38 |
 Nausea | 2 | 15 | 2 | 18 | 7 | 21 | 11 | 19 |
 Dizziness | 2 | 15 | 2 | 18 | 7 | 21 | 11 | 19 |
 Dyspnea | 2 | 15 | 3 | 27 | 6 | 18 | 11 | 19 |
 Peripheral edema | 0 | 0 | 2 | 18 | 9 | 26 | 11 | 19 |
 Rash | 2 | 15 | 1 | 9 | 7 | 21 | 10 | 17 |
 Cough | 1 | 8 | 3 | 27 | 7 | 21 | 11 | 19 |
 Decreased appetite | 2 | 15 | 0 | 0 | 5 | 15 | 7 | 12 |
 Diarrhea | 0 | 0 | 1 | 9 | 7 | 21 | 8 | 14 |
 Headache | 3 | 23 | 1 | 9 | 2 | 6 | 6 | 10 |
 Pyrexia | 1 | 8 | 0 | 0 | 5 | 15 | 6 | 10 |
 Vomiting | 0 | 0 | 2 | 18 | 4 | 12 | 6 | 10 |
 Constipation | 0 | 0 | 0 | 0 | 6 | 18 | 6 | 10 |
Laboratory investigations | ||||||||
 Platelet count decreased | 2 | 15 | 1 | 9 | 3 | 9 | 6 | 10 |
 White blood cell count decreased | 1 | 8 | 1 | 9 | 4 | 12 | 6 | 10 |