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Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: Role of tumor suppressor p53 and micro-RNA interplay in multiple myeloma pathogenesis

Fig. 2

Proposed scheme for the role of BMSCs in modulation of p53-miRNA interaction in association with stroma-induced drug resistance in MM. Following interaction between BMSCs and MM cells, p53 mRNA and protein and some p53-related TS-miRs (miR-15a/16-1) will be downregulated. On the other hand, the expression of some oncomiRs which negatively regulate p53 such as miR-125a, b will be promoted. Interestingly, exosomes released from BMSCs also contain miRNAs which affect p53 pathway. The outcome can be attenuation of p53-mediated apoptotic effects and drug resistance (CAMDR). It is established that integrin activation and cytokine signaling pathways will cross-talk with p53 pathway which ends in modulation of the pathway and also post-transcriptional changes in p53. However, it requires thorough investigations whether pathways activated following BMSC-MM cell interaction somehow impinge on transcriptional modulation of TP53 or miRNA genes in the nucleus through epigenetic mechanisms, miRNA biogenesis, or gene activation

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