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Table 1 List of kinase targets identified in liposarcoma cell lines by high-throughput siRNA screening

From: Kinase profiling of liposarcomas using RNAi and drug screening assays identified druggable targets

Symbol

Gene name

Cell line (liposarcoma histotype)

EGFR

Epidermal growth factor receptor

SW872 (undifferentiated)

PTK2

Protein tyrosine kinase 2 (or focal adhesion kinase)

LPS141 (dedifferentiated)

T778 (well-differentiated)

TXK

Tyrosine-protein kinase

LPS141 (dedifferentiated)

SYK

Spleen tyrosine kinase

LP6 (dedifferentiated)

FER

FER (Fps/Fes related) tyrosine kinase

SA4 (dedifferentiated)

KDR

Kinase insert domain receptor

SA4 (dedifferentiated)

KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

T449 (well-differentiated)

MLS402 (myxoid)

GOT3 (well-differentiated)

PDGFRA

Platelet-derived growth factor receptor, alpha polypeptide

T449 (well-differentiated)

LiSa-2 (pleomorphic)

STYK1

Serine/threonine/tyrosine kinase 1

T778 (well-differentiated)

EPHA6

Ephrin type-A receptor 6

T778 (well-differentiated)

ROR1

Receptor tyrosine kinase-like orphan receptor 1

MLS402 (myxoid)

JAK1

Janus kinase 1

FU-DDLS-1 (dedifferentiated)

MATK

Megakaryocyte-associated tyrosine kinase

FU-DDLS-1 (dedifferentiated)

LiSa-2 (pleomorphic)

ROS1

ROS proto-oncogene 1, receptor tyrosine kinase

FU-DDLS-1 (dedifferentiated)

MST1R

Macrophage stimulating 1 receptor

LiSa-2 (pleomorphic)

FLT3

Fms-related tyrosine kinase 3

T1000 (well-differentiated)

JAK2

Janus kinase 2

T1000 (well-differentiated)