Table 1 Examples of targeted drugs for AML
Target | Drug | Phase of development |
|---|---|---|
PLKs | Volasertib | 3 |
FLT3 | Sorafenib | 2 |
| Â | Midostaurin (PKC412) | 3 |
| Â | Quizartinib (AC220) | 3 |
| Â | Crenolanib (CP868596) | 2 |
| Â | Gilteritinib (ASP2215) | 3 |
| Â | Lestaurtinib (CEP-701) | 3 |
DNMTs | Azacitidine (5-Aza) | Approved |
| Â | Decitabine | Approved |
| Â | Guadecitabine (SGI-110) | 3 |
| Â | Sapacitabine (CYC682) | 3 |
IDH2 | AG-221 | 3 |
IDH1 | AG-120 | 2 |
HDACs | Vorinostat | 3 |
| Â | Entinostat | 2 |
BET | OTX015 | 1 |
DOT1L | Pinometostat (EPZ-2676) | 1 |
LSD1 | GSK2879552 | 1 |
CD33 | GO | 3 |
SGN-33A | 3 | |
CD33 CART | Preclinical | |
CD123 | CSL362 | Preclinical |
SL-401 | Preclinical | |
CD123 CART | Preclinical | |
PD-1 | Nivolumab | 2 |
CTLA4 | Ipilimumab | 2 |