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Fig. 5 | Journal of Hematology & Oncology

Fig. 5

From: Cell adhesion-mediated mitochondria transfer contributes to mesenchymal stem cell-induced chemoresistance on T cell acute lymphoblastic leukemia cells

Fig. 5

Cell-cell adhesion mediates mitochondria transfer from Jurkat cells to MSCs. Anti-ICAM-1 (20 mg/ml) was added to the coculture system with MTX for 48 h. a Confocal images showed that mitochondria transfer was inhibited by anti-ICAM-1. Scale bar, 10 μm. b The areas of red foci per field were calculated by ImageJ software. c Flow cytometry analysis of MitoTracker Red uptake by MSCs (GFP+ population) cocultured with MitoTracker Red-labeled Jurkat cells for 48 h. d The percentage of Red+ MSCs in each group was analyzed and graphed. The data above are presented as the mean ± S.E.M. of three independent experiments (*P < 0.05; **P < 0.01; t test)

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