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Fig. 4 | Journal of Hematology & Oncology

Fig. 4

From: SF3B1 deficiency impairs human erythropoiesis via activation of p53 pathway: implications for understanding of ineffective erythropoiesis in MDS

Fig. 4

Activation of p53 pathway in SF3B1-knockdown CFU-E cells. a The top 5 up- and downregulated pathways revealed by GSEA analysis of the differentially expressed genes between luciferase and SF3B1 knockdown CFU-E cells. b The mRNA levels of TP53, BAX, p21, and BBC3 revealed by RNA-seq analysis. c The mRNA levels of TP53, BAX, p21, and BBC3 revealed by real-time PCR analysis; β-actin was used as internal control. *P < 0.05, **P < 0.01, ***P < 0.01. d Representative western blotting showing the expression of P53, BAX, p21, and BBC3 in erythroblasts cultured for 7 days

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