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Fig. 6 | Journal of Hematology & Oncology

Fig. 6

From: SF3B1 deficiency impairs human erythropoiesis via activation of p53 pathway: implications for understanding of ineffective erythropoiesis in MDS

Fig. 6

Activation of p53 pathway is due to decreased expression of large isoform of MKRN1. a Representative western blotting showing the expression of SF3B1 and MKRN1 large isoform in cells transduced with luciferase-shRNA and SF3B1-shRNA. b Growth curves of cells transduced with luciferase-shRNA, SF3B1-shRNA2/pGFP, and SF3B1-shRNA2/pGFP-MKRN1. c Quantitative analysis of apoptosis of cells transduced with luciferase-shRNA, SF3B1-shRNA2/pGFP, and SF3B1-shRNA2/pGFP-MKRN1. d Representative western blot analysis showing the expression of p53, BAX, p21, and BBC3 in cells transduced with luciferase-shRNA, SF3B1-shRNA2/pGFP, and SF3B1-shRNA2/pGFP-MKRN1

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Journal of Hematology & Oncology

ISSN: 1756-8722

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