Fig. 3

The underlying mechanisms of the PD-1, PD-L1 and PD-L2 associations with prognosis. a Cluster analysis and heat map visualization of immune checkpoint-related genes, OS and HUVOS grade. b Heat map visualization of the differentially expressed genes between the PD-1 high-expression group and PD-1 low-expression group, c GSEA analysis of PD-1 and d gene annotation network analysis of the differentially expressed genes. e Heat map visualization of the differentially expressed genes between the PD-L1 high-expression group and PD-L1 low-expression group, f GSEA analysis of PD-L1 and g gene annotation network analysis of the differentially expressed genes. h Heat map visualization of the differentially expressed genes between the PD-L2 high-expression group and PD-L2 low-expression group, i GSEA analysis of PD-L2 and j gene annotation network analysis of the differentially expressed genes