The consensus on indications, conditioning regimen, and donor selection of allogeneic hematopoietic cell transplantation for hematological diseases in China—recommendations from the Chinese Society of Hematology

Table 7 Conditioning regimens for severe aplastic anemia

Conditioning regimen	Drug	Dose (total)	Time(d)	Transplantation type
International regimen
Cy-ATG	Cy	200 mg/kg	−5 ~ − 22	HLA-matched sibling HSCT
Cy-ATG	ATG	11.25 ~ 15.00 mg/kg	−5 ~ − 3, − 2	HLA-matched sibling HSCT
FluCy-ATG	Flu	120 mg/m²	−5 ~ − 2	HLA-matched unrelated HSCT
	Cy	120 mg/kg	−5, − 2
	ATG	11.25 ~ 15.00 mg/kg	−5 ~ − 3, − 2
Regimens in China
mBuCyATG-SAA	Bu	6.4 mg/kg(ivgtt)	−7, − 6	Haploidentical-HSCT
	Cy	200 mg/kg	−5, − 2
	ATG	10 mg/kg	−5 ~ − 2
	or ATG-F	40 mg/kg	−5 ~ − 2
mBuCyFluATG	Bu	6,4mg/kg(ivgtt)	−7 ~ − 6	Haploidentical-HSCT
	Flu	120 mg/m²	−10 ~ − 7
	Cy	200 mg/kg	−6 ~ − 3
	ATG-F	20 mg/kg	−4 ~ − 1
	or ATG	10 mg/kg	−4 ~ − 1
FluCy-ATG	Flu	120 mg/m²	−5 ~ − 2	Haploidentical-HSCT
	Cy	90 mg/kg	−3, − 2
	ATG	10 mg/kg	−5 ~ − 2

Cy cyclophosphamide, ATG anti-thymocyte globulin thymoglobuline, ATG-F rabbit anti-thymocyte globulin produced by Fresenius, Flu fludarabine, Bu busulfan, allo-HSCT allogeneic hematological stem cell transplantation

ISSN: 1756-8722