Table 8 Conditioning regimens for thalassemia
Conditioning regimen | Drug | Dose | Time(d) | Transplantation |
|---|---|---|---|---|
General intensity | ||||
Regimens for leukemia | The same as leukemia | Same as leukemia | Allo-HSCT | |
BuCy | Bu | 14 mg/kg(po) | Allo-HSCT | |
Cy | 200 mg/kg | |||
Intensified regimen | ||||
NF0-8-TM | Cy | 110 mg/kg | −10, −9 | HLA-matched sibling transplantation |
Flu | 200 mg/m2 | −8 ~ − 4 | Unrelated HLA-matched transplantation | |
TT | 10 mg/kg | −5 | ||
Bu | ivgtt,QD(−8d) Css 300 ~ 600 ng/L | −8 ~ − 6 | Haploidentical-HSCT | |
Azathioprine | 3 mg/kg,QD | From D−45 | ||
Hu | 30 mg/kg,QD | From D−45 | ||
FluBuCyATG | Flu | 150mg/m2 | −12 ~ − 10 | Allo-HSCT |
Bu | 12.8 mg/kg(ivgtt) | −9 ~ − 6 | ||
Cy | 200 mg/kg | −5 ~ − 2 | ||
ATG | 10 mg/kg | −5 ~ − 2 | ||
Hu | 20 mg/kg,QD | 3 months before | ||