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Table 3 Grading of Recommendations Assessment, Development and Evaluation (GRADE)

From: Standardizing haematopoietic cell transplants in China

Code

Quality of evidence

Definition

A

High

Further research is very unlikely to change our confidence in the estimate of effect.

• Several high-quality studies with consistent results

• In special cases: one large, high-quality multi-centre trial

B

Moderate

Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.

• One high-quality study

• Several studies with some limitations

C

Low

Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.

• One or more studies with severe limitations

D

Very low

Any estimate of effect is very uncertain.

• Expert opinion

• No direct research evidence

• One or more studies with very severe limitations