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Table 3 Definition of high-dose vasopressors

From: Grading of cytokine release syndrome associated with the CAR T cell therapy tisagenlecleucel

Vasopressor

Dose for ≥ 3 h

Norepinephrine monotherapy

≥ 0.20 mcg/kg/min

Dopamine monotherapy

≥ 10 mcg/kg/min

Phenylephrine monotherapy

≥ 200 mcg/min

Epinephrine monotherapy

≥ 0.10 mcg/min

If on vasopressin

High-dose if vasopressin + norepinephrine equivalent of ≥ 10 mcg/min (using VASST formula)*

If on combination vasopressors (not vasopressin)

Norepinephrine equivalent of ≥ 20 mcg/min (using VASST formula)*

  1. Adapted from Russel et al. with adjustments to accommodate weight-based dosing [42]
  2. *VASST (Vasopressin and Septic Shock Trial) vasopressor equivalent equation: \( {\displaystyle \begin{array}{l}\mathrm{Norepinephrine}\ \mathrm{equivalent}\ \mathrm{dose}=\left[\mathrm{norepinephrine}\ \left(\mathrm{mcg}/\min \right)\right]+\left[\mathrm{dopamine}\ \left(\mathrm{mcg}/\mathrm{kg}/\min \right)\div 2\right]\ \\ {}+\left[\mathrm{epinephrine}\ \left(\mathrm{mcg}/\min \right)\right]+\left[\mathrm{phenylephrine}\ \left(\mathrm{mcg}/\min \right)\div 10\right]\end{array}} \)