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Table 1 Correlation between clinicopathologic parameters and NLRX1 expression status

From: NOD-like receptor X1 functions as a tumor suppressor by inhibiting epithelial-mesenchymal transition and inducing aging in hepatocellular carcinoma cells

Clinical and pathologic indexes

 

High NLRX1

Low NLRX1

 
 

n = 382

%

n = 193

%

P

Age, years

≤ 50

149

36.3

70

33.7

0.586

> 50

293

63.7

123

66.3

 

Gender

Male

382

86.5

167

86.4

1.000

Female

60

13.5

26

13.6

 

HBsAg

Negative

87

28.0

54

19.7

0.023

Positive

355

72.0

139

80.3

 

With liver cirrhosis

No

7

1.60

3

1.60

1.000

Yes

435

98.4

190

98.4

 

GGT (U/L)

≤ 54

141

31.1

60

31.9

0.853

> 54

301

68.9

133

68.1

 

AFP (ng/mL)

≤400

280

50.8

98

63.3

0.004

> 400

162

49.2

95

36.7

 

Tumor number

Single

323

75.6

146

73.1

0.556

Multiple

119

24.4

47

26.9

 

Tumor size, cm

≤ 5

216

40.9

79

48.9

0.070

> 5

226

59.1

114

51.1

 

Tumor encapsulation

Complete

219

56.0

108

49.5

0.143

None

223

44.0

85

50.5

 

Edmondson stage

I-II

333

62.7

121

75.3

0.002

II-IV

109

37.3

72

24.7

 

BCLC stage

0-A

279

77.1

111

77.1

1.000

B-C

83

22.9

33

22.9

 

PVTT

None

278

48.2

93

62.9

0.010

Yes

164

51.8

100

37.1

 
  1. Abbreviations: AFP α-fetoprotein, BCLC Barcelona Clinic Liver Cancer, GGT gamma-glutamyl transpeptidase, HBsAg hepatitis B virus surface antigen, NLRX1 nucleotide-binding oligomerization domain-like receptor X1, PVTT portal vein tumor thrombus