Fig. 6From: The first-in-class alkylating deacetylase inhibitor molecule tinostamustine shows antitumor effects and is synergistic with radiotherapy in preclinical models of glioblastomaRadiosensitizing effects of TINO on tumor weight and time to progression in U251 and T98G xenograft models. a Analysis of tumor weights harvested at the end of experiment (50th day from randomization) in U251MG xenografts. b Kaplan-Meier curves generated for time to progression in U251: comparisons amongst RT, TMZ, and TINO single therapies. c Kaplan-Meier curves generated for time to progression: analysis of radio-sensitizing effects of TINO for U251G xenografts in comparison with TMZ and RT + TMZ. d Forest plots (U251) for the comparison of TTP distribution in different treatments with untreated animals (vehicle). e Forest plots (U251) for comparison of TTP in the different combination regimens. f Analysis of tumor weights harvested at the end of experiment (35th day from randomization) in T98G xenografts. g Kaplan-Meier curves generated for time to progression in T98G: comparisons amongst RT, TMZ, and TINO single therapies. h Kaplan-Meier curves generated for time to progression: analysis of radio-sensitizing effects of TINO for T98G xenografts in comparison with TMZ and RT + TMZ. i Forest plots for the comparison of TTP distribution in different treatments with untreated animals (vehicle). j Forest plots for comparison of TTP in the different combination regimensBack to article page