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Fig. 6 | Journal of Hematology & Oncology

Fig. 6

From: The first-in-class alkylating deacetylase inhibitor molecule tinostamustine shows antitumor effects and is synergistic with radiotherapy in preclinical models of glioblastoma

Fig. 6

Radiosensitizing effects of TINO on tumor weight and time to progression in U251 and T98G xenograft models. a Analysis of tumor weights harvested at the end of experiment (50th day from randomization) in U251MG xenografts. b Kaplan-Meier curves generated for time to progression in U251: comparisons amongst RT, TMZ, and TINO single therapies. c Kaplan-Meier curves generated for time to progression: analysis of radio-sensitizing effects of TINO for U251G xenografts in comparison with TMZ and RT + TMZ. d Forest plots (U251) for the comparison of TTP distribution in different treatments with untreated animals (vehicle). e Forest plots (U251) for comparison of TTP in the different combination regimens. f Analysis of tumor weights harvested at the end of experiment (35th day from randomization) in T98G xenografts. g Kaplan-Meier curves generated for time to progression in T98G: comparisons amongst RT, TMZ, and TINO single therapies. h Kaplan-Meier curves generated for time to progression: analysis of radio-sensitizing effects of TINO for T98G xenografts in comparison with TMZ and RT + TMZ. i Forest plots for the comparison of TTP distribution in different treatments with untreated animals (vehicle). j Forest plots for comparison of TTP in the different combination regimens

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