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Table 1 Exosomal miRNAs in HCC development

From: Exosomal miRNAs in hepatocellular carcinoma development and clinical responses

Exosomal miRNAs Donor cells Recipient cells Target genes Functions Ref.
miR-122 Huh7 cells HepG2 cells CAT1, FTF2B, etc. Inhibit growth and proliferation and increase senescence of HepG2 cells [16]
miR-122 AMSCs HepG2 cells ADAM10, IGF1R, CCNG1 Render HepG2 cells more sensitive to chemotherapeutic agents and inhibit HCC cells proliferation [43]
miR-9-3p a a HBGF-5 Reduce HCC cell viability and proliferation and reduce expression of ERK1/2 [36]
miR-335-5p LX2 cells MHCC97L, MHCC97H, Huh7, and HepG2 cells CDC42, TCF3, CDK2, etc. Inhibit recipient cell proliferation and invasion and reduce HCC tumor in size [18]
miR-1247-3p LM3 cells Normal fibroblasts in lung tissues B4GALT3 Promote the conversion of normal fibroblasts to CAFs and accelerate lung metastasis of HCC [25]
miR-320a CAFs MHCC97-H cells and SMMC-7721 cells PBX3 Inhibit tumor progression by suppressing MAPK pathway [27]
miR-142, miR-223 Macrophages Huh7 cells STMN1 Inhibit HCC cell proliferation [28]
miR-490 Mast cells HepG2 and Hep3B cells ERGIC3 Suppress EGFR/AKT/ERK1/2 pathway and inhibit migration of HCC cells [20]
miR-584, miR-517c, miR-378, etc. Hep3B cells HepG2 cells TAK1, TAB2, etc. Associate with hepatocarcinogenesis and enhance transformed cell growth in recipient cells [21]
miR-155 Arsenite-transformed L-02 cells Native L-02 and THLE-3 cells QKI Promote inflammatory infiltration and HCC [24]
  1. aExosomal miR-9-3p is from serum in this research, so no donor cells and recipient cells are mentioned