Table 1 Exosomal miRNAs in HCC development
From: Exosomal miRNAs in hepatocellular carcinoma development and clinical responses
Exosomal miRNAs | Donor cells | Recipient cells | Target genes | Functions | Ref. |
|---|---|---|---|---|---|
miR-122 | Huh7 cells | HepG2 cells | CAT1, FTF2B, etc. | Inhibit growth and proliferation and increase senescence of HepG2 cells | [16] |
miR-122 | AMSCs | HepG2 cells | ADAM10, IGF1R, CCNG1 | Render HepG2 cells more sensitive to chemotherapeutic agents and inhibit HCC cells proliferation | [43] |
miR-9-3p | a | a | HBGF-5 | Reduce HCC cell viability and proliferation and reduce expression of ERK1/2 | [36] |
miR-335-5p | LX2 cells | MHCC97L, MHCC97H, Huh7, and HepG2 cells | CDC42, TCF3, CDK2, etc. | Inhibit recipient cell proliferation and invasion and reduce HCC tumor in size | [18] |
miR-1247-3p | LM3 cells | Normal fibroblasts in lung tissues | B4GALT3 | Promote the conversion of normal fibroblasts to CAFs and accelerate lung metastasis of HCC | [25] |
miR-320a | CAFs | MHCC97-H cells and SMMC-7721 cells | PBX3 | Inhibit tumor progression by suppressing MAPK pathway | [27] |
miR-142, miR-223 | Macrophages | Huh7 cells | STMN1 | Inhibit HCC cell proliferation | [28] |
miR-490 | Mast cells | HepG2 and Hep3B cells | ERGIC3 | Suppress EGFR/AKT/ERK1/2 pathway and inhibit migration of HCC cells | [20] |
miR-584, miR-517c, miR-378, etc. | Hep3B cells | HepG2 cells | TAK1, TAB2, etc. | Associate with hepatocarcinogenesis and enhance transformed cell growth in recipient cells | [21] |
miR-155 | Arsenite-transformed L-02 cells | Native L-02 and THLE-3 cells | QKI | Promote inflammatory infiltration and HCC | [24] |