Fig. 1

Chemical basis and diverse molecular functions of m⁶A RNA methylation. m⁶A RNA methylation is modulated by its “writers,” “erasers,” and “readers.” Writers refer to the m⁶A methylase complex which is consisted of METTL3, METTL14, WTAP, RBM15, and KIAA1429. Erasers are m⁶A demethylases including FTO and ALKBH5. Readers are proteins that bind to m⁶A modifications and exert various functions, some of whom identified so far are YTHDF1, YTHDF2, YTHDF3, YTHDC1, YTHDC2, and hnRNPA2B1. m⁶A RNA methylation is known to be involved in all stages in the life cycle of RNA including pre-mRNA splicing, pri-miRNA processing, through nuclear export, RNA translation modulation and RNA degradation