Journal of Hematology & Oncology

Table 3 Patients’ characteristics

From: MiR-16 regulates the pro-tumorigenic potential of lung fibroblasts through the inhibition of HGF production in an FGFR-1- and MEK1-dependent manner

Subgroup	No. of subjects	miR16 levels^a
Subgroup	No. of subjects	All	p value	CAF	p value	NF	p value
Sex
Male	19	925 [441–2120]	0.746	925 [487–1961]	0.570	1180 [312–2109]	0.855
Female	7	1330 [966–1641]		1314 [1012–2427]		1347 [700–1494]
Age
< 70	15	1227 [384–1979]	0.567	1307 [649–2069]	0.750	1120 [252–1774]	0.470
> 70	11	1105 [528–2120]		919 [531–2095]		1519 [606–1987]
Histology
Adenocarcinoma	19	1112 [475–1519]	0.488	1105 [733–1466]	0.960	1120 [290–1519]	0.147
Others	7	2078 [493–2475]		1307 [487–2966]		2216 [916–2442]
Stage
I–II	9	1105 [528–1520]	0.566	800 [486–1224]	0.520	1433 [762–1537]	0.950
III–IV	17	1227 [384–2295]		1307 [733–2456]		1120 [281–2120]
Grade
G2	4	1217 [916–1479]]	0.946	1390 [1261–2230]	0.628	734 [277–1219]	0.490
G3	16	922 [452–1658]		922 [553–2003]		1094 [286–1572]
Smoking
Current	12	860 [310–1437]	0.215	1074 [722–2584]	0.980	324 [223–972]	0.006
Former^b/Never	14	1470 [733–2120]		1126 [517–1590]		1589 [1494–2237]
COPD (GOLD)
0	15	1553 [826–2467]	0.048	1307 [616–2711]	0.456	2078 [1494–2412]	0.004
1–2	10	800 [324–1233]		860 [508–1331]		349 [281–1120]

^aData are median [IQR] of gTotalGeneSignal (Agilent Array)
^bFormer smoker > 12 months

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ISSN: 1756-8722

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