Fig. 5
From: DACH1 antagonizes CXCL8 to repress tumorigenesis of lung adenocarcinoma and improve prognosis
Overexpression of DACH1 repressed the CXCL8 level in vitro. a A549 and SKLU cells stably expressing DACH1 were confirmed by immunofluorescence assay. b Overexpression of DACH1 intuitively reduced the CXCL8 secreted by SKLU and A 549 cell lines, and c the quantitative graph showed marked statistical significance. d The protein level of CXCL8 in the supernatant of SKLU-DACH1 and A549-DACH1 cells was significantly lower compared with SKLU-vector and SKLU-vector cells. e The protein abundance of CXCL8 was repressed in SKLU cells stably expressing DACH1. f The mRNA level of CXCL8 was restrained in SKLU and A549 cells steadily expressing DACH1