Fig. 4
FLT3L CAR-T cells prolonged the survival of AML mice. a, b FLT3+ AML NOD/SCID murine model. Histopathologic analysis of bone marrow and flow cytometry analysis of bone marrow, liver, and spleen showed intensive infiltration of leukemic cells. c MV4-11 cells (5 × 106 per mouse) were injected into mice intravenously, 7 and 14 days after leukemia cells inoculation, and 1 × 107 CAR-T cells or VEC-T cells were injected intravenously, n = 7 mice per group. d Weight change from the day MV4-11 was injected is shown. e Kaplan-Meier survival curves for mice with MV4-11, treated with CAR-T or VEC-T cells. p = 0.0039, as determined by log-ranked test