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Table 1 The significance and function of CD44 isoforms

From: The biology and role of CD44 in cancer progression: therapeutic implications

CD44 isoforms Biological functions Cancer types References
CD44s Tumor growth, metastasis, low survival rate Pancreatic cancer [13]
CD44s Progression Breast cancer [54]
CD44v3 Migration, overexpressed in tumor tissue Head and neck squamous cell carcinoma [80]
CD44v3 Proliferation and cisplatin resistance Head and neck squamous cell carcinoma [81]
CD44v4, CD44v5 Lung metastasis loci Pancreatic cancer [68]
CD44v6 Metastasis; association with liver metastasis Pancreatic cancer [60, 61, 67]
CD44v6 Epithelial phenotype cells expression Prostate cancer [75]
CD44v6 Tumorigenic and chemoresistance Prostate cancer [57]
CD44v6 Migration, metastasis, advanced stage of tumor Colorectal adenocarcinomas [15, 63]
CD44v6 Metastasis Colon cancer [15]
CD44v6,CD44v9 Correlates with lymph node metastasis, liver metastasis, and TNM stage Pancreatic cancer [56]
CD44v9 Lower survival rate, correlates with lymph node/liver metastasis, and TNM stage Pancreatic cancer [56]
CD44v9 Associated with worse prognosis, contributed to EMT-mediated invasion and migration Bladder cancer [200]
CD44v9 Inhibited assembly of p-cMet, AR, HSP90, P110α/PI3K, and CD44 into lipid raft like structures Prostate cancer [76]
CD44v4-10 Promoted adenoma initiation in Apc(Min/+)mice, tumor initiation Colorectal cancer [88]
CD44v8-10 Tumor initiation Gastric cancer [89]
CD44v8-10 Lung metastasis Breast cancer [70]
CD44v (v6-10,v7-10,v8-10) Correlative study of CD44v expression on transgenic Gan mice Gastric tumor [86]
CD44v8-10 overexpression Enhance chronic phase CML progenitor replacing capacity Leukemia [201]
CD44, isoforms not specified Correlative study of CD44 expression on malignant stage Prostate cancer [73]
CD44, isoforms not specified Increased colony formation, invasion Prostate cancer [79]
CD44, isoforms not specified Poor prognosis, low survival rate, metastasis Pancreatic cancer [69]