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Fig. 1 | Journal of Hematology & Oncology

Fig. 1

From: Decitabine demonstrates antileukemic activity in B cell precursor acute lymphoblastic leukemia with MLL rearrangements

Fig. 1

HMA interfere with biological cell functions. SEM and RS4;11 cells were exposed to HMA for up to 72 h. Results were expressed as a percentage of DMSO-treated control cells and displayed as mean ± SD of three independent experiments. Significant treatment effects vs. DMSO are labeled with * (p < 0.05). a Proliferation and metabolic activity of SEM cells were significantly reduced after AZA and DEC exposure. HMA did not influence proliferation or metabolic activity of RS4;11 cells. b HMA induced an increase of SEM cells in G1/G0 phase, with a decreased number of cells in S phase. c In SEM cells, HMA increase the amount of early apoptotic and late apoptotic cells compared to DMSO-treated cells. Effect of DEC treatment was stronger than the effect of AZA treatment. No induction of apoptosis was observed in RS4;11 cells

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