Table 1 Drugs used to treat hematological and solid malignancies which are effective or highly effective in the inhibition of rRNA transcription or processing (modified from Burger et al., 2010) [5]

 Melphalan*

 Cisplatin*

 Oxaliplatin*

 Cyclophosphamide ¹ *

 Doxorubicin *

 Mitoxantrone *

 Actinomycin D *

 Mitomycin C

 Methotrexate *

 5-Fluorouracil

 Topoisomerase inhibitors:

 Camptothecin

 Etoposide*

 Flavopiridol*

 Roscovitine

 Rapamycin

 Bortezomib*

 Homoharringtonine*

 Vinblastine*

 CX-5461 ² *