Fig. 7

STARD13-correlated ceRNA network regulates YAP nuclear abundance by inhibiting RhoA-ROCK signaling. a Confocal images of YAP distribution in MCF-7 cells with STARD13-correlated ceRNAs knockdown. b Confocal images of YAP-5SA distribution in MDA-MB-231 cells with STARD13-correlated ceRNAs-3′UTR overexpression or not. Overexpression of STARD13-correlated ceRNAs-3′UTRs could promote YAP-5SA cytoplasmic retention even when it could not be phosphorylated by LATS1/2. c Glisa assay of MDA-MB-231 cells with STARD13-correlated ceRNAs-3′UTR overexpression. Overexpression of STARD13-correlated ceRNAs-3′UTRs impaired RhoA activity in MDA-MB-231 cells. d Western blot assay of lysates from MDA-MB-231 cells described in c. Overexpression of STARD13-correlated ceRNAs-3′UTRs in MDA-MB-231 cells dephosphorylated MLC. e Confocal images of filamentous actin (F-actin) stained with rhodamine-labeled phalloidin in MDA-MB-231 cells described in c. f Confocal images of YAP distribution in MCF-7 cells with STARD13-correlated ceRNA knockdown plus ROCK inhibitor (Y-27632) treatment or not. g Confocal images of YAP-5SA distribution in MDA-MB-231 cells with ROCK inhibitor (Y-27632) treatment or not. Data were presented as the mean ± SD, n = 3, **p < 0.01 vs. pLVX-Ctrl