Fig. 9

Proposed model that STARD13-correlated ceRNA network inhibits breast cancer EMT and CSC formation, and thus drug resistance. STARD13-correalted ceRNA network acts as a potential inhibitor of YAP transcriptional activity at least through two concurring pathways: one is by facilitating LATS1/2 expression via ceRNA interaction and the other is by blocking RhoA-F-actin signaling cascade through Rho GTPase activity of STARD13. This inhibition results in EMT prohibition and inhibits breast CSC formation, and thus enhances drug sensitivity