Fig. 3
From: Wnt signaling in multiple myeloma: a central player in disease with therapeutic potential
Wnt signaling in hematopoietic stem cells and early B cell development. Wnt signaling is essential for HSC self-renewal capacity and is also active in precursor cells from fraction A. Fraction B pro-B cells, that undergo IgH rearrangement, have an active Wnt pathway and express high levels of LEF1 and Fzd9. Also, large pre-B cells from fraction C that greatly expand their population express LEF1 and Fzd9 and have an active Wnt pathway. Small pre-B cells from fraction D stop proliferating and start rearranging IgL genes. Upon expression of IgM, Wnt pathway activity is expected to be terminated