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Table 1 Rare TRK fusions in diverse tumor types

From: Basket trial of TRK inhibitors demonstrates efficacy in TRK fusion-positive cancers

Tumor type NTRK1/2/3 involved (frequency) Detection methods
Ph-like acute lymphoblastic leukemia NTRK3 (1/154) RNA-seq, whole-genome seq, whole-exome seq [18]
Appendiceal adenocarcinoma NTRK (unspecified) (2/97) MALDI-TOF mass spectroscopy genotyping (Sequenom), targeted NGS (MSK-IMPACT) [19]
Astrocytoma NTRK2 (3/96) RNA-seq, whole-genome seq [20]
Breast invasive carcinoma NTRK3 (1/1072) RNA-seq (TCGA) [21]
Intrahepatic cholangiocarcinoma NTRK1 (1/28) Targeted NGS [22]
Colon adenocarcinoma NTRK1 (8/1559) IHC, RT-PCR [23]
NTRK1 (1/66) IHC, RT-PCR [24]
NTRK3 (2/286) RNA-seq (TCGA) [21]
GIST NTRK3 (1/186) Targeted NGS (Foundation Medicine) [25]
NTRK3 (1/31) RNA-seq, FISH, RT-PCR [26]
Glioblastoma NTRK1 (1/157) RNA-seq (TCGA) [21]
NTRK1 (2/185) RNA-seq (TCGA and other) [27]
NTRK1 (3/115) Targeted NGS [28]
Brain low-grade glioma NTRK2 (2/461) RNA-seq (TCGA) [21]
Pediatric DIPG and non-brainstem high-grade glioma NTRK1 (3/127) RNA-seq, whole-genome seq [29]
NTRK2 (3/127) RNA-seq, whole-genome seq [29]
NTRK3 (2/127) RNA-seq, whole-genome seq [29]
Head and neck squamous cell carcinoma NTRK2 (1/411) RNA-seq (TCGA) [21]
NTRK3 (1/411) RNA-seq (TCGA) [21]
Congenital mesoblastic nephroma NTRK3 (5/6) RT-PCR, FISH [30]
NTRK3 (10/15) RT-PCR [31]
NTRK3 (13/19) FISH [32]
Infantile (congenital) fibrosarcoma NTRK3 (10/11) RT-PCR, IHC [33]
NTRK3 (5/5) RT-PCR, FISH [30]
Lung adenocarcinoma NTRK1 (3/91) Targeted NGS (Foundation Medicine), FISH [34]
NTRK2 (1/513) RNA-seq (TCGA) [21]
Breast secretory carcinoma NTRK3 (12/13) RT-PCR, FISH [35]
NTRK3 (9/9) FISH, targeted NGS [36]
Mammary analogue secretory carcinoma (MASC) of salivary glands NTRK3 (13/14) RT-PCR, FISH [37]
NTRK3 (15/15) FISH [38]
NTRK3 (5/6) FISH, targeted NGS [36]
NTRK3 (16/20) RT-PCR, FISH [39]
Melanoma (skin cutaneous) NTRK3 (1/374) RNA-seq (TCGA) [21]
Spitz tumors and spitzoid melanoma NTRK1(23/140) Targeted NGS(Foundation Medicine), FISH, IHC [40]
Sarcoma (NOS) NTRK1 (1/103) RNA-seq (TCGA) [21]
Uterine sarcoma NTRK1 (3/97) RNA-seq, FISH, IHC, targeted NGS [41]
NTRK3 (1/97) RNA-seq, FISH, IHC, targeted NGS [41]
Thyroid carcinoma NTRK1 (5/498) RNA-seq (TCGA) [21]
NTRK3 (7/498) RNA-seq (TCGA) [21]
Papillary thyroid carcinoma NTRK1 (15/119) RT-PCR [42]
NTRK1 (2/38) Southern [43]
NTRK1(pediatric) (1/27) Targeted NGS [44]
NTRK3(radiation-associated) (2/26) RNA-seq [45]
NTRK3(radiation-associated) (9/62) RNA-seq [46]
NTRK3(sporadic) (3/151) RNA-seq [46]
NTRK3(pediatric) (6/27) Targeted NGS [44]