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Table 1 Rare TRK fusions in diverse tumor types

From: Basket trial of TRK inhibitors demonstrates efficacy in TRK fusion-positive cancers

Tumor type

NTRK1/2/3 involved (frequency)

Detection methods

Ph-like acute lymphoblastic leukemia

NTRK3 (1/154)

RNA-seq, whole-genome seq, whole-exome seq [18]

Appendiceal adenocarcinoma

NTRK (unspecified) (2/97)

MALDI-TOF mass spectroscopy genotyping (Sequenom), targeted NGS (MSK-IMPACT) [19]

Astrocytoma

NTRK2 (3/96)

RNA-seq, whole-genome seq [20]

Breast invasive carcinoma

NTRK3 (1/1072)

RNA-seq (TCGA) [21]

Intrahepatic cholangiocarcinoma

NTRK1 (1/28)

Targeted NGS [22]

Colon adenocarcinoma

NTRK1 (8/1559)

IHC, RT-PCR [23]

NTRK1 (1/66)

IHC, RT-PCR [24]

NTRK3 (2/286)

RNA-seq (TCGA) [21]

GIST

NTRK3 (1/186)

Targeted NGS (Foundation Medicine) [25]

NTRK3 (1/31)

RNA-seq, FISH, RT-PCR [26]

Glioblastoma

NTRK1 (1/157)

RNA-seq (TCGA) [21]

NTRK1 (2/185)

RNA-seq (TCGA and other) [27]

NTRK1 (3/115)

Targeted NGS [28]

Brain low-grade glioma

NTRK2 (2/461)

RNA-seq (TCGA) [21]

Pediatric DIPG and non-brainstem high-grade glioma

NTRK1 (3/127)

RNA-seq, whole-genome seq [29]

NTRK2 (3/127)

RNA-seq, whole-genome seq [29]

NTRK3 (2/127)

RNA-seq, whole-genome seq [29]

Head and neck squamous cell carcinoma

NTRK2 (1/411)

RNA-seq (TCGA) [21]

NTRK3 (1/411)

RNA-seq (TCGA) [21]

Congenital mesoblastic nephroma

NTRK3 (5/6)

RT-PCR, FISH [30]

NTRK3 (10/15)

RT-PCR [31]

NTRK3 (13/19)

FISH [32]

Infantile (congenital) fibrosarcoma

NTRK3 (10/11)

RT-PCR, IHC [33]

NTRK3 (5/5)

RT-PCR, FISH [30]

Lung adenocarcinoma

NTRK1 (3/91)

Targeted NGS (Foundation Medicine), FISH [34]

NTRK2 (1/513)

RNA-seq (TCGA) [21]

Breast secretory carcinoma

NTRK3 (12/13)

RT-PCR, FISH [35]

NTRK3 (9/9)

FISH, targeted NGS [36]

Mammary analogue secretory carcinoma (MASC) of salivary glands

NTRK3 (13/14)

RT-PCR, FISH [37]

NTRK3 (15/15)

FISH [38]

NTRK3 (5/6)

FISH, targeted NGS [36]

NTRK3 (16/20)

RT-PCR, FISH [39]

Melanoma (skin cutaneous)

NTRK3 (1/374)

RNA-seq (TCGA) [21]

Spitz tumors and spitzoid melanoma

NTRK1(23/140)

Targeted NGS(Foundation Medicine), FISH, IHC [40]

Sarcoma (NOS)

NTRK1 (1/103)

RNA-seq (TCGA) [21]

Uterine sarcoma

NTRK1 (3/97)

RNA-seq, FISH, IHC, targeted NGS [41]

NTRK3 (1/97)

RNA-seq, FISH, IHC, targeted NGS [41]

Thyroid carcinoma

NTRK1 (5/498)

RNA-seq (TCGA) [21]

NTRK3 (7/498)

RNA-seq (TCGA) [21]

Papillary thyroid carcinoma

NTRK1 (15/119)

RT-PCR [42]

NTRK1 (2/38)

Southern [43]

NTRK1(pediatric) (1/27)

Targeted NGS [44]

NTRK3(radiation-associated) (2/26)

RNA-seq [45]

NTRK3(radiation-associated) (9/62)

RNA-seq [46]

NTRK3(sporadic) (3/151)

RNA-seq [46]

NTRK3(pediatric) (6/27)

Targeted NGS [44]