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Fig. 4 | Journal of Hematology & Oncology

Fig. 4

From: Combating head and neck cancer metastases by targeting Src using multifunctional nanoparticle-based saracatinib

Fig. 4

Nano-sar inhibits the Src signaling pathways, migration, and invasion in HNSCC cells. a The effects of saracatinib (Sar) and Nano-sar on Src phospho-activation and the downstream pathways. b The effects of Sar and Nano-sar on colony formation of HNSCC cells within 2 weeks. In this assay, colonies with more than 50 cells were scored and counted under the microscope. c, d The effects of Sar and Nano-sar on migration and invasion of HNSCC cells within 24 h. In bd, the representative images and quantitative data were shown in the left and right panels, respectively. e The effects of Sar and Nano-sar on 3D invasion in Matrigel within 72 h. *p < 0.05; **p < 0.01

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