Fig. 5

Nano-sar has superior effects on suppression of head and neck tumor metastasis than the free drug in mice. a–c Tumor growth curve, tumor weight, and body weight for mice treated with phosphate-buffered saline vehicle control, saracatinib (Sar), or Nano-sar (n = 5/group). d Tumor progression and metastasis monitored by examining bioluminescence in Xenogen IVIS-200 In Vivo imaging system. e The number of nodules on the lung surface. f Histology examination (HE staining) of the lung sections for mice treated with saline vehicle control, Sar, or Nano-sar. g Histology examination (HE staining) of tissues taken from major organs after therapy.*p < 0.05; **p < 0.01