Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in cancer

Huang, Xinwei; Zhang, Hong; Guo, Xiaoran; Zhu, Zongxin; Cai, Haibo; Kong, Xiangyang

doi:10.1186/s13045-018-0628-y

Journal of Hematology & Oncology

Table 1 The expression and roles of IGF2BP1 in human cancer

From: Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in cancer

Cancer type	Incidence	Method	The status of expression in tissues	The roles of IGF2BP1 expression in cancers	Reference
Lung cancer and esophageal adenocarcinomas
Non-small cell lung cancer	27% (4/11)–52% (139/267)	Microarray, qRT-PCR, Western blot	Overexpressed	Promoting lung cancer development and progression	[8, 33]
Lung adenocarcinoma	17% (1/6)	IHC, TCGA datasets	Significantly upregulated	Poor overall survival; bigger primary tumor size	[32, 34, 79]
Lung squamous cell carcinoma	37.5% (3/8)	IHC, TCGA datasets	Significantly upregulated	Younger age at diagnosis	[32, 79]
Esophageal adenocarcinomas	Unknown	TCGA datasets	Significantly upregulated	Poor survival	[34]
Breast cancer
Breast cancer	59% (59/118)	IHC, immunofluorescence, Western Blotting, RNASeq	High and ubiquitously expressed	Tumorigenic activity, clonogenic growth	[1, 8]
Breast cancer		qRT-PCR	Wildly expressed	Inhibiting tumor growth and metastasis	[17, 54,55,56,57]
Liver cancer
Gallbladder carcinoma	72.4%	IHC	Ubiquitously expressed but lower expressed than controls	Longer survival	[38]
Hepatocellular carcinoma	Unknown	TCGA, IHC, qRT-PCR, Western blot		Poor survival	[3]
Hepatocellular carcinoma		qRT-PCR, Western blot	Overexpressed	Positively correlated with tumor size, advanced stages and grading of poor differentiation	[41]
Hepatocellular carcinoma		IHC	Significantly upregulated	Promoting progression; migration and invasion	[40]
Hepatocellular carcinoma		IHC	Significantly upregulated	Poor prognosis	[42]
Hepatocellular carcinoma		qRT-PCR, Western blot	Significantly upregulated	Promoting tumor cell proliferation, migration, and invasion	[39]
Hepatocellular carcinoma		ELISA, qRT-PCR, Western blot	Significantly upregulated	Poor post-surgery prognosis	[43]
Hepatocellular carcinoma		qRT-PCR	Significantly upregulated		[52]
Fibrolamellar hepatocellular carcinoma (FL-HCC)	Unknown	ACGH, RNA-seq	Significantly upregulated		[50]
Leukemia
Chronic myelogenous leukemia (CML)	Unknown	qRT-PCR	Significantly upregulated	Promoting cell proliferation	[97]
Acute lymphoblastic leukemia (ALL)	Unknown		Overexpressed		[98]
Melanoma
Melanoma	34% (13/38)	RT-PCR	Upregulated	Promoting tumor growth and drug resistance	[8, 87,88,89]
Osteosarcoma (OS)
Osteosarcoma (OS)	Unknown	Western blot	High expression	Promoting the proliferation, migration and invasion, and growth of tumor cell, and inhibiting apoptosis	[76]
Gastrointestinal cancer
Colon	50% (36/79)–59% (46/78)	IHC		Tumor-suppressive role	[8, 16]
Colon	50% (36/79)–59% (46/78)	qRT-PCR, immunofluorescence, IHC, Western Blotting	Upregulated	Promoting cell proliferation, growth, and survival	[67]
CNS cancer
Neuroblastoma	Unknown	Microarray data	High expression	Poor survival, advanced stages	[80]
Glioblastoma multiforme (GBM)	54.5% (6/11)	qRT-PCR, Western blotting	Significantly upregulated	Inducing carcinogenesis and metastasis	[44, 79]
Meningiomas	63.6% (14/22)	Western blotting	Reduced expression	Promoting tumor development and the malignant potential	[81, 79]
Rhabdomyosarcomas (RMS)	Unknown	IHC	Overexpressed tumors and cell lines	Regulating cell death and drug resistance	[78]
Gynecologic cancers
Cervical cancer (CC)	Unknown	Western blotting, qRT-PCR	Significantly upregulated	Promoting cell viability, migration, and invasion	[59, 60]
Ovarian cancer	69% (73/106)	IHC	High expression	Poor prognosis and poor overall survival	[8, 61]
Other cancers
Choriocarcinoma (CC)	Unknown	IHC, Western blotting, qRT-PCR	Overexpressed	Promoting cell migration and invasion	[100]
Retinoblastoma	Unknown	LC–MS/MS,IHC	Overexpressed	Promoting cell proliferation and migration	[99]

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ISSN: 1756-8722

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