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Fig. 1 | Journal of Hematology & Oncology

Fig. 1

From: T cell senescence and CAR-T cell exhaustion in hematological malignancies

Fig. 1

Schematic model of age and HCMV infection related T cell immunosenescence in the peripheral blood of human. Memory inflation due to latent HCMV infections and thymic involution lead to a shift in T cell distribution from mainly naïve and memory T cells towards effector and senescent T cells with progressing age. Senescent T cells are characterized by shortening of telomeric ends, decrease in telomerase activity, and loss of CD27 and CD28 expression. Markers of T cell senescence include KRLG1, CD57, and the recently identified receptor TIGIT

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