Table 1 Most common ERBB2 mutations in cancer patients
From: Targeting ERBB2 mutations in solid tumors: biological and clinical implications
Mutation | Frequency in GENIE database (%) | Proportion of ERBB2 mutations (%) | Type of mutation | Function |
|---|---|---|---|---|
S310F/Y | 0.46 | 12.6 | Missense | Activating |
Y772_A775dup | 0.21 | 6.9 | In Frame | Activating |
R678Q | 0.17 | 4.5 | Missense | Activating |
L755S/A/P | 0.17 | 5.5 | Missense | Activating |
V777L/M | 0.12 | 4.0 | Missense | Activating |
V842I | 0.09 | 3.1 | Missense | Activating |
D769Y/H/N | 0.09 | 2.9 | Missense | Inactivating |