Fig. 1
From: Immune cell subset differentiation and tissue inflammation
General processes of hematopoietic stem cell differentiation. Long-term hematopoietic stem cells (LT-HSC) differentiate into common lymphoid progenitors (CLP) and common myeloid progenitors (CMP). CLP are committed to lymphoid genesis and differentiate into B cells (BC), T cells (TC), and natural killer T cells (NKT) (1). CMP are committed to megaerythroid genesis and could differentiate into erythrocytes and platelets (2). CMP could also differentiate into granulocyte-macrophage progenitors (GMP), and then differentiate into granulocytes (neutrophils (NØ), eosinophils, basophils, and mast cells) and “NØ-like” MC. In addition, CMP could differentiate into monocyte-dendritic progenitors (MDP), which are committed to myeloid genesis and differentiate into common dendritic cell progenitor (CDP)-derived plasmocytoid dendritic cells (pDC) and common monocyte precursor (cMoP)-derived monocytes (MC), which further differentiate into monocyte-derived DC (mDC) and macrophages (MØ) (3)