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Fig. 6 | Journal of Hematology & Oncology

Fig. 6

From: Immune cell subset differentiation and tissue inflammation

Fig. 6

Model of differentiation of inflammatory mononuclear cell, their interaction with endothelial cells and contribution to lymphocyte subset differentiation and tissue inflammation. In early stage of atherosclerosis, Ly6Cmiddle + high monocytes (MC) transmigrate to sub-endothelial space of vessel and further differentiate to M1 macrophages (MØ) and monocyte-derived dendritic cells (mDC). mDC activate T helper cells Th1, Th17, and B2 cells, resulting in chronic inflammation in atherosclerotic plaque. All of these inflammatory mononuclear cell subsets promote atherosclerosis development partially through production of proinflammatory cytokines

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