Table 3 Representative immune cell subset changes in human diseases
From: Immune cell subset differentiation and tissue inflammation
Cells | Changes | Tissues | PMID# |
|---|---|---|---|
Atherosclerosis (carotid/coronary atherosclerosis, stenosis, cardiovascular death, nonhemorrhagic stroke) | |||
TC | TC↑, PD-1+Tim-3+CD8+ TC↑, Th17/Th1 TC↑Th1 TC↑, CD4+LAP+ or CD4+CD25+ Treg TC↓CD3+CD4+CD45RA−CD45RO+CCR7− T(EM) TC↑ | PBMC | 260352072152475023130116 |
BC | TC/BC↑ | Fibro-fatty (aorta, coronary) | 24122585 |
MC | CD14++CD16+ MC↑, CD14++CD16−CCR2+ MC↑CD14+CD16++CCR2- MC↑ | PBMC | 2299972825012963 |
MØ | CD86+ M1 MØ↑, M2 MØ↑ | PBMC, rupture-prone shoulder regions, Adventitial tissue | 23078881 |
Acute myocardial infarction | |||
TC | CD3+CD4+CD45RA−CD45RO+CCR7− T(EM) TC↑HLA-DR+ T(EM) TC↑ | PBMC | 23121518 |
MC | CD14++CD16-CCR2+TLR4+ MC↑CD14+CD16++CCR2+TLR4+ MC↑ | PBMC | 23121518 |
Hypercholesterolemia (total serum C levels > 200 mg/dl or 6.5 mmol/L, LDL-C > 160 mg/dl, serum TG ≤ 300 mg/dl) | |||
TC | CD3+ TC↑, CD4+ TC↑, CD8+ TC↑ | PBMC | 8546748 |
MC | CD14dimCD16+ non-classical MC↑CD64−CD16+ non-classical MC↑ | PBMC | 103812988977447 |
Infection (HCMV with CAP, HIV on stable ART with CAC) | |||
TC | Lymphocyte↑, CD3+ TC↑, CD4+ TC↑, CD8+ TC↑, Th1 TC↑, CD4+CD25+Foxp3+ Treg TC↓CD8+IL-6Rαlow T(EM) TC↑, CD8+CD57+ TC↑ | Subintimal PBMC | 239689792636053027062409 |
MC | CD14++CD16+ MC↑, CD14++CD16- MC↑CD14+CD16++ MC↓, CD14+CD16++ MC↑ | PBMC | 2636053024118494 |
Chronic kidney diseases | |||
MC | CD14+CD16+ non-classical MC↑ | PBMC | 26,877,933 |
Early rheumatoid arthritis, systemic lupus erythematosus | |||
TC | CD8+CD31+CXCR4+ TC↑ | PBMC | 1780453027065298 |
Obese, pre-diabetes, diabetes mellitus type 2 | |||
TC | NKT-like TC↑, CD3+CD56+ NKT TC↑ | PBMC | 24554505 |
MC | CD14++CD16+ MC↑, CD14+CD16++ MC↑ | PBMC | 21799175 |
Endarterectomy (CEA and endarterectomy at the femoropopliteal level) | |||
TC | NKTs↑, TC↑ | PBMC, plaques | 27051078 |
DC | CD11b+ cDC↑ | PBMC, plaques | 27051078 |
MØ | MMP-12+CD68+ MØ↑ | Culprit sections | 23316311 |
Colorectal cancer | |||
TC | NKT cells↑ | PBMC | 22220404 |