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Fig. 6 | Journal of Hematology & Oncology

Fig. 6

From: Ube2v1-mediated ubiquitination and degradation of Sirt1 promotes metastasis of colorectal cancer by epigenetically suppressing autophagy

Fig. 6

Ube2v1 expression in clinical samples of colorectal cancer. a mRNA levels of Ube2v1 in a tumor and its adjacent tissue from a CRC patient using qPCR. b Scores for Ube2v1 staining in paired, adjacent normal and tumor tissue samples from CRC patients by immunohistochemical staining. Typical staining for Ube2v1 in paired, adjacent normal and tumor tissue sample from a CRC patient. c Scores for Ube2v1 staining in tumor samples from CRC patients with or without distant metastasis by immunohistochemical staining. d Scores for Ube2v1 staining in tumor samples from CRC patients with different TNM stages by immunohistochemical staining. Typical staining for Ube2v1 in tumor samples from CRC patients in TNM stage I and stage IV was shown. e Disease-free survival of CRC patients according to the expression levels of Ube2v1 mRNA by PrognoScan using data from Public Gene Expression Profile (GSE17537). Statistical significance was determined by using a two-tailed, unpaired Student’s t test. *p < 0.05

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