Table 2 Combination index values of AZD-1775 in combination with bosutinib (Bos) on BCR-ABL1-positive cell lines
From: Targeting WEE1 to enhance conventional therapies for acute lymphoblastic leukemia
24 h | 48 h | |||||||
|---|---|---|---|---|---|---|---|---|
BOS (nM) | BOS (nM) | |||||||
Cell line | 10 | 25 | 50 | 10 | 25 | 50 | ||
BV-173 | AZD-1775 (nM) | 6.9 | 0.95 | 1.11 | 0.99 | 1.45 | 1.03 | 1.27 |
20.6 | 1.03 | 1.21 | 1.01 | 1.59 | 0.98 | 1.29 | ||
61.7 | 0.73 | 0.86 | 0.62 | 0.88 | 0.72 | 1.08 | ||
185.2 | 0.71 | 0.77 | 0.71 | 0.59 | 0.65 | 1.01 | ||
555.6 | 1.26 | 0.75 | 0.61 | 0.85 | 0.78 | 1.03 | ||
1666.7 | 1.14 | 0.92 | 0.81 | 1.08 | 1.08 | 1.24 | ||
5000.0 | 1.82 | 1.71 | 1.58 | 2.44 | 1.86 | 2.02 | ||
Cell line | 500 | 1000 | 2000 | 500 | 1000 | 2000 | ||
SUP-B15 | AZD-1775 (nM) | 6.9 | 0.52 | 0.96 | 1.23 | 0.59 | 0.84 | 1.23 |
20.6 | 0.64 | 0.72 | 1.11 | 0.61 | 0.99 | 0.98 | ||
61.7 | 0.7 | 1.36 | 0.91 | 0.73 | 0.83 | 0.89 | ||
185.2 | 1.05 | 1.51 | 0.79 | 0.79 | 0.88 | 0.79 | ||
555.6 | 1.07 | 1.3 | 1.14 | 1.18 | 1.22 | 1 | ||
1666.7 | 0.44 | 0.54 | 0.46 | 0.5 | 0.55 | 0.54 | ||
5000.0 | 0.51 | 0.49 | 0.4 | 0.41 | 0.41 | 0.31 | ||